| http://purl.uniprot.org/citations/8373826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8373826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8373826 | http://www.w3.org/2000/01/rdf-schema#comment | "The plant aromatic alcohol dehydrogenase, cinnamyl alcohol dehydrogenase (CAD2 from Eucalyptus) was found by sequence analysis of its cloned gene to be homologous to a range of dehydrogenases including alcohol dehydrogenases, L-threonine-3-dehydrogenase, D-xylose reductase and sorbitol dehydrogenase. A homology model of CAD2 was built using the X-ray crystallographic coordinates of horse-liver alcohol dehydrogenase to provide the template, with additional modelling input from other analogous regions of structure from similar enzymes where necessary. The structural model thus produced rationalised the Zn-binding properties of CAD2, indicated the possession of a Rossmann fold (GXGXXG motif), and explained the class A stereospecificity (pro-R hydrogen removal from substrate alcohol) and aromatic substrate specificity of the enzyme. A range of potential ligands was designed based on the homology model and tested as inhibitors of CAD2 and horse liver alcohol dehydrogenase."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.org/dc/terms/identifier | "doi:10.1016/0167-4838(93)90063-w"xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.org/dc/terms/identifier | "doi:10.1016/0167-4838(93)90063-w"xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Goffner D."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Goffner D."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Baltas M."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Baltas M."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Boudet A.M."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Boudet A.M."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Douglas K.T."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Douglas K.T."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Feuillet C."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Feuillet C."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Gorrichon L."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Gorrichon L."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Grima-Pettenati J."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Grima-Pettenati J."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Jahouri R."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "Jahouri R."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "McKie J.H."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/author | "McKie J.H."xsd:string |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8373826 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |