| http://purl.uniprot.org/citations/8383326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8383326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8383326 | http://www.w3.org/2000/01/rdf-schema#comment | "This report describes the isolation and recombinant expression of a cDNA clone encoding HER4, the fourth member of the human epidermal growth factor receptor (EGFR) family. The HER4/erbB4 gene encodes a 180-kDa transmembrane tyrosine kinase (HER4/p180erbB4) whose extracellular domain is most similar to the orphan receptor HER3/p160erbB3, whereas its cytoplasmic kinase domain exhibits 79% and 77% identity with EGFR and HER2/p185erbB2, respectively. HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. In addition, we describe the partial purification of a heparin-binding HER4-stimulatory factor from HepG2 cells. This protein was found to specifically stimulate the intrinsic tyrosine kinase activity of HER4/p180erbB4 while having no direct effect on the phosphorylation of EGFR, HER2, or HER3. Furthermore, this heparin-binding protein induces phenotypic differentiation, and tyrosine phosphorylation, of a human mammary tumor cell line that overexpresses both HER4 and HER2. These findings suggest that this ligand-receptor interaction may play a role in the growth and differentiation of some normal and transformed cells."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.90.5.1746"xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.90.5.1746"xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Green J.M."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Green J.M."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Shoyab M."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Shoyab M."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Neubauer M.G."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Neubauer M.G."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Carlton G.W."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Carlton G.W."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Culouscou J.-M."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Culouscou J.-M."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Plowman G.D."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Plowman G.D."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Whitney G.S."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Whitney G.S."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Foy L."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/author | "Foy L."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8383326 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |