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| http://purl.uniprot.org/citations/8384306 | http://www.w3.org/2000/01/rdf-schema#comment | "The myeloperoxidase (MPO) gene is expressed specifically in myeloid cells. There is significant homology between the murine and human MPO genes in the 1.6-kb region located upstream of the murine MPO transcription initiation sites. 5',3', and internal deletions of this DNA segment localized several cis-acting DNA elements in the murine MPO promoter which are functional in 32D cl3 cells, a murine myeloblast cell line which expresses MPO. These DNA elements did not function well in mouse L-cell fibroblasts. Additional mutagenesis of the most active promoter region allowed the delimitation of a functional 20-bp segment. Mutation of the enhancer core motif within this segment was functionally deleterious, and an oligonucleotide containing these base pairs increased the activity of a minimal promoter. This same oligonucleotide, but not a mutant variant, could bind a set of nuclear proteins, myeloid nuclear factors 1 alpha and 1 beta (MyNF1 alpha and -1 beta), present in 32D cl3 cells but absent from L cells, murine erythroleukemia cells, and SP2 lymphoid cells."xsd:string |
| http://purl.uniprot.org/citations/8384306 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.13.4.2141-2151.1993"xsd:string |
| http://purl.uniprot.org/citations/8384306 | http://purl.uniprot.org/core/author | "Friedman A.D."xsd:string |
| http://purl.uniprot.org/citations/8384306 | http://purl.uniprot.org/core/author | "Suzow J."xsd:string |
| http://purl.uniprot.org/citations/8384306 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8384306 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/8384306 | http://purl.uniprot.org/core/pages | "2141-2151"xsd:string |
| http://purl.uniprot.org/citations/8384306 | http://purl.uniprot.org/core/title | "The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1)."xsd:string |
| http://purl.uniprot.org/citations/8384306 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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