| http://purl.uniprot.org/citations/8387214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8387214 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription of the human erythropoietin (EPO) gene is activated in Hep3B cells exposed to hypoxia. Hypoxia-inducible factor 1 (HIF-1) is a nuclear factor whose DNA binding activity is induced by hypoxia in Hep3B cells, and HIF-1 binds at a site in the EPO gene enhancer that is required for hypoxic activation of transcription. In this paper, we demonstrate that HIF-1 DNA binding activity is also induced by hypoxia in a variety of mammalian cell lines in which the EPO gene is not transcribed. The composition of the HIF-1 DNA binding complex and its isolated DNA binding subunit and the mechanism of HIF-1 activation appear to be similar or identical in EPO-producing and non-EPO-producing cells. Transcription of reporter genes containing the EPO gene enhancer is induced by hypoxia in non-EPO-producing cells and mutations that eliminate HIF-1 binding eliminate inducibility. These results provide evidence that HIF-1 and its recognition sequence are common components of a general mammalian cellular response to hypoxia."xsd:string |
| http://purl.uniprot.org/citations/8387214 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.90.9.4304"xsd:string |
| http://purl.uniprot.org/citations/8387214 | http://purl.uniprot.org/core/author | "Wang G.L."xsd:string |
| http://purl.uniprot.org/citations/8387214 | http://purl.uniprot.org/core/author | "Semenza G.L."xsd:string |
| http://purl.uniprot.org/citations/8387214 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8387214 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/8387214 | http://purl.uniprot.org/core/pages | "4304-4308"xsd:string |
| http://purl.uniprot.org/citations/8387214 | http://purl.uniprot.org/core/title | "General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia."xsd:string |
| http://purl.uniprot.org/citations/8387214 | http://purl.uniprot.org/core/volume | "90"xsd:string |
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