| http://purl.uniprot.org/citations/8393786 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8393786 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8393786 | http://www.w3.org/2000/01/rdf-schema#comment | "[Arg8]vasopressin and oxytocin are the two main members of the neurohypophysial hormone family found to be present in nearly all mammals. [Lys8]vasopressin ([Lys8]VP) has been identified as the antidiuretic hormone in pig and some marsupial families. The porcine-derived kidney epithelial cell line, LLC-PK1, expresses both [Lys8]VP receptors coupled to the activation of adenylate cyclase (V2 receptors) and oxytocin receptors. Here we report the molecular cloning of the V2 [Lys8]VP receptor and the oxytocin receptor from LLC-PK1 cells. The cloned V2 [Lys8]VP receptor differs from human and rat V2 [Arg8] receptors mainly in its N-terminal region, in residues located in the extracellular loops and in intracellular phosphorylation sites. When expressed in COS7 cells, the V2 [Lys8]VP receptor exhibits the relative order of ligand affinity [Lys8]VP = [Arg8]VP >> 1-deamino[D-Arg8]VP > or = oxytocin and adenylate-cyclase stimulation, expected for the porcine V2 [Lys8]VP receptor but different from V2 [Arg8]VP receptors. Adenylate-cyclase activation by [Lys8]VP was inhibited in COS7 cells by a V2 antagonist. The cloned oxytocin receptor exhibits in COS7 cells a ligand specificity typical of mammalian oxytocin receptors. mRNA-distribution analysis revealed a single 5.5-kb transcript in the uterus from pregnant guinea pig."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1993.tb18000.x"xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1993.tb18000.x"xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/author | "Fahrenholz F."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/author | "Fahrenholz F."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/author | "Akhundova A."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/author | "Akhundova A."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/author | "Buechner H."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/author | "Buechner H."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/author | "Gorbulev V."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/author | "Gorbulev V."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/pages | "1-7"xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/pages | "1-7"xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/title | "Molecular cloning and functional characterization of V2 [8-lysine] vasopressin and oxytocin receptors from a pig kidney cell line."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/title | "Molecular cloning and functional characterization of V2 [8-lysine] vasopressin and oxytocin receptors from a pig kidney cell line."xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/volume | "215"xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://purl.uniprot.org/core/volume | "215"xsd:string |
| http://purl.uniprot.org/citations/8393786 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8393786 |
| http://purl.uniprot.org/citations/8393786 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8393786 |