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| http://purl.uniprot.org/citations/8394370 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal growth factors regulate the expression of voltage-activated sodium current in differentiating sympathetic neurons and PC12 cells. We show that, in PC12 cells, the NGF- and FGF-induced sodium current results from increased expression of two distinct sodium channel types. Sodium current results from the rapid induction of a novel sodium channel transcript, also found in peripheral neurons, and from the long term induction of brain type II/IIA mRNA. Expression of the type II/IIA sodium channel requires activation of the cyclic AMP-dependent protein kinase (A-kinase), whereas induction of the peripheral neuron type sodium channel occurs through an A-kinase-independent signal transduction pathway. These findings suggest that the two sodium channel types act in concert to ensure the generation of action potentials during neuronal differentiation."xsd:string |
| http://purl.uniprot.org/citations/8394370 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.122.4.915"xsd:string |
| http://purl.uniprot.org/citations/8394370 | http://purl.uniprot.org/core/author | "Brehm P."xsd:string |
| http://purl.uniprot.org/citations/8394370 | http://purl.uniprot.org/core/author | "Mandel G."xsd:string |
| http://purl.uniprot.org/citations/8394370 | http://purl.uniprot.org/core/author | "Shepherd D."xsd:string |
| http://purl.uniprot.org/citations/8394370 | http://purl.uniprot.org/core/author | "Halegoua S."xsd:string |
| http://purl.uniprot.org/citations/8394370 | http://purl.uniprot.org/core/author | "D'Arcangelo G."xsd:string |
| http://purl.uniprot.org/citations/8394370 | http://purl.uniprot.org/core/author | "Paradiso K."xsd:string |
| http://purl.uniprot.org/citations/8394370 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8394370 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/8394370 | http://purl.uniprot.org/core/pages | "915-921"xsd:string |
| http://purl.uniprot.org/citations/8394370 | http://purl.uniprot.org/core/title | "Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways."xsd:string |
| http://purl.uniprot.org/citations/8394370 | http://purl.uniprot.org/core/volume | "122"xsd:string |
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