| http://purl.uniprot.org/citations/8396993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8396993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8396993 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified cDNAs representing three hexokinase mRNAs (Hk1-sa, Hk1-sb, Hk1-sc) by screening mouse spermatogenic cell cDNA libraries with a mouse hepatoma cell line hexokinase (Hk1) cDNA [Arora KK, Fanciulli M, Pederson PL. J Biol Chem 1990; 265:6481-6488]. Although all three cDNAs show 99% identity to the somatic Hk1 cDNA sequence throughout most of their coding region, they differ from this sequence at the 5' end. They contain a common spermatogenic cell-specific sequence and a sequence unique to each cDNA immediately 5' to the common domain. However, they lack the porin-binding domain (PBD) present in this region of Hk1, used for binding to a pore-forming protein in the outer mitochondrial membrane. These observations appear to support a model proposed by others for hexokinase gene evolution in mammals. In addition, we found that Hk1-sb has an internal sequence that is not present in Hk1, Hk1-sa, or Hk1-sc. Moreover, Hk1-sa and Hk1-sb transcripts are developmentally expressed in mouse spermatogenic cells. Hk1-sa mRNA is first expressed during meiosis and continues to be present in postmeiotic germ cells, while the more abundant Hk1-sb mRNA is detected only in postmeiotic germ cells. These and other findings suggest that enzymes encoded by Hk1-sa, Hk1-sb, and Hk1-sc are present only in spermatogenic cells."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.org/dc/terms/identifier | "doi:10.1095/biolreprod49.2.191"xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.org/dc/terms/identifier | "doi:10.1095/biolreprod49.2.191"xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/author | "Mori C."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/author | "Mori C."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/author | "O'Brien D.A."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/author | "O'Brien D.A."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/author | "Welch J.E."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/author | "Welch J.E."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/author | "Eddy E.M."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/author | "Eddy E.M."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/author | "Fulcher K.D."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/author | "Fulcher K.D."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/name | "Biol. Reprod."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/name | "Biol. Reprod."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/pages | "191-203"xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/pages | "191-203"xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/title | "Unique hexokinase messenger ribonucleic acids lacking the porin-binding domain are developmentally expressed in mouse spermatogenic cells."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/title | "Unique hexokinase messenger ribonucleic acids lacking the porin-binding domain are developmentally expressed in mouse spermatogenic cells."xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/8396993 | http://purl.uniprot.org/core/volume | "49"xsd:string |