| http://purl.uniprot.org/citations/8397339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8397339 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription of lymphokine genes in activated T cells is inhibited by the immunosuppressive agents cyclosporin A and FK506, which act by blocking the phosphatase activity of calcineurin. NFAT, a DNA-binding protein required for interleukin-2 gene transcription, is a potential target for calcineurin, cyclosporin A and FK506. NFAT contains a subunit (NFATp) which is present in unstimulated T cells and which forms a complex with Fos and Jun proteins in the nucleus of activated T cells. Here we report that NFATp is a DNA-binding phosphoprotein of relative molecular mass approximately 120,000 and is a substrate for calcineurin in vitro. Purified NFATp forms DNA-protein complexes with recombinant Jun homodimers or Jun-Fos heterodimers; the DNA-binding domains of Fos and Jun are essential for the formation of the NFATp-Fos-Jun-DNA complex. The interaction between the lymphoid-specific factor NFATp and the ubiquitous transcription factors Fos and Jun provides a novel mechanism for combinatorial regulation of interleukin-2 gene transcription, which integrates the calcium-dependent and the protein-kinase C-dependent pathways of T-cell activation."xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.org/dc/terms/identifier | "doi:10.1038/365352a0"xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/author | "Verdine G.L."xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/author | "Miner Z."xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/author | "Curran T."xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/author | "Rao A."xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/author | "Kerppola T.K."xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/author | "McCaffrey P.G."xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/author | "Jain J."xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/author | "Lambert J.N."xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/pages | "352-355"xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/title | "The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun."xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://purl.uniprot.org/core/volume | "365"xsd:string |
| http://purl.uniprot.org/citations/8397339 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8397339 |
| http://purl.uniprot.org/citations/8397339 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8397339 |
| http://purl.uniprot.org/uniprot/#_P63098-mappedCitation-8397339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8397339 |
| http://purl.uniprot.org/uniprot/#_Q12968-mappedCitation-8397339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8397339 |
| http://purl.uniprot.org/uniprot/#_Q13469-mappedCitation-8397339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8397339 |
| http://purl.uniprot.org/uniprot/#_O95644-mappedCitation-8397339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8397339 |
| http://purl.uniprot.org/uniprot/#_P16298-mappedCitation-8397339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8397339 |
| http://purl.uniprot.org/uniprot/#_Q08209-mappedCitation-8397339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8397339 |
| http://purl.uniprot.org/uniprot/#_P0DP23-mappedCitation-8397339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8397339 |