| http://purl.uniprot.org/citations/8406025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8406025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8406025 | http://www.w3.org/2000/01/rdf-schema#comment | "Several cDNA clones encoding human N-methyl-D-aspartate receptor (hNR1) subunit polypeptides were isolated from a human hippocampus library. Degenerate oligodeoxyribonucleotide (oligo) primers based on the published rat NR1 (rNR1) amino acid (aa) sequence [K. Moriyoshi et al. Nature 354 (1991) 31-37] amplified a 0.7-kb fragment from a human hippocampus cDNA library, via the polymerase chain reaction (PCR). This fragment was used as a probe for subsequent hybridization screening. DNA sequence analysis of 28 plaque-purified clones indicated three distinct classes, designated hNR1-1, hNR1-2 and hNR1-3, presumably generated by alternative RNA splicing. One of these clones, hNR1-1(5A), was isolated as a full-length cDNA. The hNR1-2 and hNR1-3 cDNAs represented 66.8 and 98.9%, respectively, of the total aa coding information predicted for the polypeptides. The hNR1 cDNAs demonstrated an 84-90.8% nucleotide (nt) identity with the corresponding rodent cDNAs. The nt sequences of hNR1-1, hNR1-2 and hNR1-3 would encode 885-, 901- and 938-aa proteins, respectively, that have 99.1-99.8% identity with the corresponding rodent NR1 (roNR1) subunits. The changes between the predicted aa sequences of hNR1 and the corresponding roNR1 subunits are confined to the extracellular N-terminal regions. We have also identified two possible allelic variations of the hNR1-3 cDNA that result in aa substitutions in the extracellular N- and C-terminal regions. One of these naturally occurring aa variations is situated within a potential glutamate-binding site."xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(93)90309-q"xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(93)90309-q"xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/author | "Kamboj R.K."xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/author | "Kamboj R.K."xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/author | "Rampersad V."xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/author | "Rampersad V."xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/author | "Foldes R.L."xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/author | "Foldes R.L."xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/pages | "293-298"xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/pages | "293-298"xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/title | "Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing."xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/title | "Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing."xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/8406025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8406025 |
| http://purl.uniprot.org/citations/8406025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8406025 |
| http://purl.uniprot.org/citations/8406025 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8406025 |
| http://purl.uniprot.org/citations/8406025 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8406025 |