| http://purl.uniprot.org/citations/8407958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8407958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8407958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/8407958 | http://www.w3.org/2000/01/rdf-schema#comment | "G/T mispairs that arise in the DNA of higher eukaryotes as a result of spontaneous hydrolytic deamination of 5-methylcytosine to thymine must be corrected to G/C pairs. We describe here the purification to apparent homogeneity of the enzyme that initiates this repair process by excising the mispaired thymine from the hetero-duplex to generate an apyrimidinic site. The enzymatic activity could be attributed to a 55-kDa polypeptide, which was purified from extracts of HeLa cells by a combination of conventional and DNA-affinity chromatography. The enzyme is a mismatch-specific thymine-DNA N-glycosylase, capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, the enzyme can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable endonucleolytic activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA."xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)36913-3"xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)36913-3"xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/author | "Jiricny J."xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/author | "Jiricny J."xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/author | "Neddermann P."xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/author | "Neddermann P."xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/pages | "21218-21224"xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/pages | "21218-21224"xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/title | "The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells."xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/title | "The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells."xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/volume | "268"xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://purl.uniprot.org/core/volume | "268"xsd:string |
| http://purl.uniprot.org/citations/8407958 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8407958 |
| http://purl.uniprot.org/citations/8407958 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8407958 |
| http://purl.uniprot.org/citations/8407958 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8407958 |
| http://purl.uniprot.org/citations/8407958 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8407958 |
| http://purl.uniprot.org/citations/8407958 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8407958 |