| http://purl.uniprot.org/citations/8408243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8408243 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatic responsiveness to beta 2-adrenergic stimulation is dynamically regulated during early development as well as following hepatic injury and disease. In the present study, the molecular mechanisms that underlie the decline in the steady-state levels of hepatic beta 2-adrenergic receptor mRNA that occurs during development in the male rat were investigated. As determined by nuclear run-on assays, an age-associated reduction in beta 2-adrenergic receptor gene transcription was observed. The transcription rate of the beta 2-adrenergic receptor gene in postnatal day 18 liver was approximately 50% lower than that of fetal liver. Stability of beta 2-adrenergic receptor gene transcripts was highest (t1/2 approximately 6h) in hepatocytes isolated from fetal rats and was lowest (t1/2 approximately 6h) in hepatocytes from postnatal day 14 rats. In fetal hepatocytes, but not postnatal day 2 hepatocytes, cycloheximide appeared to stabilize beta 2-adrenergic receptor gene transcripts in the presence of actinomycin D. These findings establish the molecular basis of reduced steady-state levels of beta 2-adrenergic receptor mRNA in liver during early postnatal development and suggest multilevel regulatory control of hepatic beta 2-adrenergic receptor gene expression."xsd:string |
| http://purl.uniprot.org/citations/8408243 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.1041570109"xsd:string |
| http://purl.uniprot.org/citations/8408243 | http://purl.uniprot.org/core/author | "Cornett L.E."xsd:string |
| http://purl.uniprot.org/citations/8408243 | http://purl.uniprot.org/core/author | "Baeyens D.A."xsd:string |
| http://purl.uniprot.org/citations/8408243 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8408243 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/8408243 | http://purl.uniprot.org/core/pages | "70-76"xsd:string |
| http://purl.uniprot.org/citations/8408243 | http://purl.uniprot.org/core/title | "Transcriptional and posttranscriptional regulation of hepatic beta 2-adrenergic receptor gene expression during development."xsd:string |
| http://purl.uniprot.org/citations/8408243 | http://purl.uniprot.org/core/volume | "157"xsd:string |
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