| http://purl.uniprot.org/citations/8421693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8421693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8421693 | http://www.w3.org/2000/01/rdf-schema#comment | "The solution structure of a diabetes-associated mutant human insulin (insulin Los Angeles; PheB24-->Ser) was determined by 13C-edited NMR spectroscopy and distance-geometry/simulated annealing calculations. Among vertebrate insulins PheB24 is invariant, and in crystal structures the aromatic ring appears to anchor the putative receptor-binding surface through long-range packing interactions in the hydrophobic core. B24 substitutions are of particular interest in relation to the mechanism of receptor binding. In one analogue ([GlyB24]insulin), partial unfolding of the B chain has been observed with paradoxical retention of near-native bioactivity. The present study of [SerB24]insulin extends this observation: relative to [GlyB24]insulin, near-native structure is restored despite significant loss of function. To our knowledge, our results provide the first structural study of a diabetes-associated mutant insulin and support the hypothesis that insulin undergoes a change in conformation on receptor binding."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.90.2.582"xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.90.2.582"xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/author | "Inouye K."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/author | "Inouye K."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/author | "Weiss M.A."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/author | "Weiss M.A."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/author | "Shoelson S.E."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/author | "Shoelson S.E."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/author | "Hua Q.-X."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/author | "Hua Q.-X."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/pages | "582-586"xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/pages | "582-586"xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/title | "Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/title | "Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus."xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/8421693 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8421693 |
| http://purl.uniprot.org/citations/8421693 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8421693 |