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http://purl.uniprot.org/citations/8423781http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8423781http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8423781http://www.w3.org/2000/01/rdf-schema#comment"A tandemly arranged multigene family encoding putative hexose transporters in Trypanosoma brucei has been characterized. It is composed of two 80% homologous groups of genes called THT1 (six copies) and THT2 (five copies). When Xenopus oocytes are microinjected with in vitro-transcribed RNA from a THT1 gene, they express a glucose transporter with properties similar to those of the trypanosome bloodstream-form protein(s). This THT1-encoded transport system for glucose differs from the human erythrocyte-type glucose transporter by its moderate sensitivity to cytochalasin B and its capacity to transport D-fructose. These properties suggest that the trypanosomal transporter may be a good target for antitrypanosomal drugs. mRNA analysis revealed that expression of these genes was life cycle stage dependent. Bloodstream forms express 40-fold more THT1 than THT2. In contrast, procyclic trypanosomes express no detectable THT1 but demonstrate glucose-dependent expression of THT2."xsd:string
http://purl.uniprot.org/citations/8423781http://purl.org/dc/terms/identifier"doi:10.1128/mcb.13.2.1146-1154.1993"xsd:string
http://purl.uniprot.org/citations/8423781http://purl.org/dc/terms/identifier"doi:10.1128/mcb.13.2.1146-1154.1993"xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/author"Bringaud F."xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/author"Bringaud F."xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/author"Baltz T."xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/author"Baltz T."xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/date"1993"xsd:gYear
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/date"1993"xsd:gYear
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/name"Mol. Cell. Biol."xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/name"Mol. Cell. Biol."xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/pages"1146-1154"xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/pages"1146-1154"xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/title"Differential regulation of two distinct families of glucose transporter genes in Trypanosoma brucei."xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/title"Differential regulation of two distinct families of glucose transporter genes in Trypanosoma brucei."xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/volume"13"xsd:string
http://purl.uniprot.org/citations/8423781http://purl.uniprot.org/core/volume"13"xsd:string
http://purl.uniprot.org/citations/8423781http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8423781
http://purl.uniprot.org/citations/8423781http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8423781
http://purl.uniprot.org/citations/8423781http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/8423781
http://purl.uniprot.org/citations/8423781http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/8423781
http://purl.uniprot.org/uniprot/Q09037http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/8423781
http://purl.uniprot.org/uniprot/Q06222http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/8423781