| http://purl.uniprot.org/citations/8444804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8444804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8444804 | http://www.w3.org/2000/01/rdf-schema#comment | "A number of Bacillus subtilis genes involved in NAD biosynthesis have been cloned and sequenced. One of the genes encodes a polypeptide homologous to Escherichia coli L-aspartate oxidase, and its mutation resulted in a nicotinic acid (Nic)-dependent phenotype; this gene was termed nadB. A second open reading frame (orf2) was found downstream of nadB, and an insertional plasmid separating orf2 and nadB also gave a Nic-dependent phenotype. This result suggests that orf2 may also be involved in NAD biosynthesis and that nadB and orf2 are in the same operon. Upstream of nadB was a third gene, transcribed in the opposite direction to that of nadB-orf2. The amino acid sequence derived from the third gene was quite similar to those derived from nifS genes of various nitrogen-fixing bacteria; therefore, the third gene was termed nifS. As with nadB and orf2, mutations in nifS also resulted in a Nic-dependent phenotype. The promoter regions of nadB and nifS overlapped each other and both contained -10 and -35 sequences which resemble those of E sigma A-type promoters. Transcription from both the nifS and nadB promoters, as well as expression of a nadB-lacZ fusion, was repressed by Nic. However, nadB transcription and nadB-lacZ expression were decreased, at most, only slightly by a deletion in nifS. The possible role of the nifS gene product in NAD biosynthesis is discussed."xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.175.5.1423-1432.1993"xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.175.5.1423-1432.1993"xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/author | "Sun D."xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/author | "Sun D."xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/author | "Setlow P.L."xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/author | "Setlow P.L."xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/name | "J. Bacteriol."xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/name | "J. Bacteriol."xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/pages | "1423-1432"xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/pages | "1423-1432"xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/title | "Cloning, nucleotide sequence, and regulation of the Bacillus subtilis nadB gene and a nifS-like gene, both of which are essential for NAD biosynthesis."xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/title | "Cloning, nucleotide sequence, and regulation of the Bacillus subtilis nadB gene and a nifS-like gene, both of which are essential for NAD biosynthesis."xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/8444804 | http://purl.uniprot.org/core/volume | "175"xsd:string |
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| http://purl.uniprot.org/citations/8444804 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8444804 |
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| http://purl.uniprot.org/citations/8444804 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8444804 |
| http://purl.uniprot.org/uniprot/P39666 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8444804 |
| http://purl.uniprot.org/uniprot/P21203 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8444804 |