| http://purl.uniprot.org/citations/8446173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8446173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8446173 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription factor DRTF1/E2F coordinates events in the cell cycle with transcription by its cyclical interactions with important regulators of cellular proliferation like the retinoblastoma tumour-suppressor gene product (Rb) and the Rb-related protein, p107 (refs 1-8). DRTF1/E2F binding sites occur in the control regions of genes involved in proliferation, and both Rb and p107 repress the capacity of DRTF1/E2F to activate transcription (refs 11, 12; M. Zamanian and N.B.L.T., manuscript submitted). Mutant Rb proteins isolated from tumour cells are unable to bind DRTF1/E2F (refs 11-13), and certain viral oncoproteins, such as adenovirus E1A, sequester Rb and p107 in order to free active DRTF1/E2F (refs 5, 11, 12, 14, 15). Here we report the isolation of a complementary DNA encoding DRTF1-polypeptide-1 (DP-1), a major sequence-specific binding protein that is present in DRTF1/E2F, including Rb- and p107-associated DRTF1/E2F. The DNA-binding domain of DP-1 contains a region that resembles that of E2F-1 (refs 16, 17), and recognizes the same sequence. DRTF1/E2F thus appears to contain at least two sequence-specific DNA-binding proteins."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.org/dc/terms/identifier | "doi:10.1038/362083a0"xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.org/dc/terms/identifier | "doi:10.1038/362083a0"xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "La Thangue N.B."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "La Thangue N.B."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Totty N.F."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Totty N.F."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Partridge J.F."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Partridge J.F."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Hsuan J.J."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Hsuan J.J."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Bandara L.R."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Bandara L.R."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Burden N."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Burden N."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Girling R."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/author | "Girling R."xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/pages | "83-87"xsd:string |
| http://purl.uniprot.org/citations/8446173 | http://purl.uniprot.org/core/pages | "83-87"xsd:string |