| http://purl.uniprot.org/citations/8450955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8450955 | http://www.w3.org/2000/01/rdf-schema#comment | "Microtubule-associated protein 1B, formerly also known as microtubule-associated protein 5, is the first structural microtubule accessory protein to appear in outgrowing axons. In PC12 pheochromocytoma cells microtubule-associated protein 1B levels increase several-fold after the addition of nerve growth factor and this increase is correlated with the initiation of process formation. To determine whether microtubule-associated protein 1B is essential for neurite outgrowth, we used antisense oligodeoxynucleotides to inhibit its expression in nerve growth factor-treated PC12 cells in the rat. The application of several different antisense oligodeoxynucleotides to the microtubule-associated protein 1B mRNA sequence inhibited both microtubule-associated protein 1B expression and neurite extension. Specificity was shown by the lack of effect of control sense oligonucleotides and by the lack of effect of the microtubule-associated protein 1B antisense oligodeoxynucleotides on the expression of either tubulin or microtubule-associated protein 3, another microtubule-associated protein whose synthesis is stimulated by nerve growth factor treatment of PC12 cells. After removal of the antisense oligodeoxynucleotides, microtubule-associated protein 1B expression recovered to normal levels and the cells grew normal neurites with the timing and morphological characteristics of normal nerve growth factor-induced outgrowth, indicating that the blockade was not because of non-specific toxic effects. These results indicate that microtubule-associated protein 1B is an essential component of the molecular mechanism underlying the formation of neuronal processes."xsd:string |
| http://purl.uniprot.org/citations/8450955 | http://purl.org/dc/terms/identifier | "doi:10.1016/0306-4522(93)90401-z"xsd:string |
| http://purl.uniprot.org/citations/8450955 | http://purl.uniprot.org/core/author | "Matus A."xsd:string |
| http://purl.uniprot.org/citations/8450955 | http://purl.uniprot.org/core/author | "Brugg B."xsd:string |
| http://purl.uniprot.org/citations/8450955 | http://purl.uniprot.org/core/author | "Reddy D."xsd:string |
| http://purl.uniprot.org/citations/8450955 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8450955 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/8450955 | http://purl.uniprot.org/core/pages | "489-496"xsd:string |
| http://purl.uniprot.org/citations/8450955 | http://purl.uniprot.org/core/title | "Attenuation of microtubule-associated protein 1B expression by antisense oligodeoxynucleotides inhibits initiation of neurite outgrowth."xsd:string |
| http://purl.uniprot.org/citations/8450955 | http://purl.uniprot.org/core/volume | "52"xsd:string |
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