| http://purl.uniprot.org/citations/8473324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8473324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8473324 | http://www.w3.org/2000/01/rdf-schema#comment | "Clones referred to as ARD 1 were isolated from human and rat cDNA libraries. ARD 1 genes encode a putative 64-kDa protein that contains an 18-kDa ADP-ribosylation factor (ARF) domain at the carboxyl terminus and is much larger than the other monomeric approximately 20-kDa guanine nucleotide-binding ARF proteins thus far identified. ARD 1 mRNAs of 3.7 and 4.1 kilobases were detected in all rat tissues as well as in mouse and rabbit brain, human fibroblasts, and human neuroblastoma cells but not in HL-60 cells. Based on sequence identities, ARD 1 is highly conserved between rat and human. The ARF domain of ARD 1 contains the consensus sequences believed to be involved in guanine nucleotide binding, which are conserved in the ARFs and other GTP-binding proteins. Recombinant ARD 1 or the ARF domain of ARD 1, which lacks the 15 amino acids corresponding to the amino-terminal regions of ARFs stimulated, in a GTP-dependent manner, cholera toxin ADP-ribosyltransferase activity in the presence of 0.3% Tween 20. It had no effect in the presence of SDS, dimyristoylphosphatidylcholine/cholate, or cardiolipin. These observations are consistent with the conclusion that the amino-terminal region of ARF proteins is not required for activation of cholera toxin. In addition, the characteristic features of ARF proteins may be found as domains of larger mammalian proteins."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)52945-8"xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)52945-8"xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/author | "Mishima K."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/author | "Mishima K."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/author | "Moss J."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/author | "Moss J."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/author | "Vaughan M."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/author | "Vaughan M."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/author | "Tsuchiya M."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/author | "Tsuchiya M."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/author | "Nightingale M.S."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/author | "Nightingale M.S."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/pages | "8801-8807"xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/pages | "8801-8807"xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/title | "ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/title | "ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain."xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/volume | "268"xsd:string |
| http://purl.uniprot.org/citations/8473324 | http://purl.uniprot.org/core/volume | "268"xsd:string |