| http://purl.uniprot.org/citations/8473338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8473338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8473338 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently we reported the isolation of cDNAs for a number of genes that are differentially expressed between nonproliferating early (young) and late (senescent) population doubling level (PDL) WI-38 human, fetal lung-derived, fibroblast-like cells. We now demonstrate that one of these isolates, EPC-1 (early PDL cDNA-1), derives from an approximately 1.4-kilobase mRNA species that is expressed at a > or = 100-fold higher level in serum-starved, confluent, young versus similarly treated senescent WI-38 cells. Complete nucleotide sequence analysis of this cDNA confirms its identity with that of a cDNA encoding a secreted, retinal pigmented epithelium differentiation factor as well as similarity of the encoded protein with a number of mammalian serine protease inhibitors. We show that EPC-1 expression is associated with G0 growth arrest in WI-38 cells. The mRNA readily accumulates in density-arrested and/or serum-starved young cells but not in log phase, low density young cells. In contrast, EPC-1 transcript abundance and expression of the encoded, secreted protein are both negligible in senescent WI-38 cells under all culture conditions tested. These findings support the hypothesis that senescent WI-38 cells exhibit a state of growth arrest fundamentally distinct from that of quiescent (G0) young cells."xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)52964-1"xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)52964-1"xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/author | "Rotenberg M.O."xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/author | "Rotenberg M.O."xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/author | "Cristofalo V.J."xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/author | "Cristofalo V.J."xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/author | "Pignolo R.J."xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/author | "Pignolo R.J."xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/pages | "8949-8957"xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/pages | "8949-8957"xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/title | "Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state."xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/title | "Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state."xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/volume | "268"xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://purl.uniprot.org/core/volume | "268"xsd:string |
| http://purl.uniprot.org/citations/8473338 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8473338 |
| http://purl.uniprot.org/citations/8473338 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8473338 |
| http://purl.uniprot.org/citations/8473338 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8473338 |
| http://purl.uniprot.org/citations/8473338 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8473338 |