| http://purl.uniprot.org/citations/8474450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8474450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8474450 | http://www.w3.org/2000/01/rdf-schema#comment | "The message for the zinc finger gene Rex-1 (Zfp-42) is expressed in undifferentiated murine F9 teratocarcinoma cells and embryonic stem cells. Expression of Rex-1 is reduced at the transcriptional level when F9 cells are induced by the addition of retinoic acid (RA) to differentiate. We have isolated genomic DNA for the Rex-1 gene (Zfp-42), characterized the gene's structure, and mapped the gene to mouse chromosome 8. Promoter elements contributing to the regulation of the Rex-1 promoter in F9 cells have been identified. A region required for Rex-1 promoter activity in F9 stem cells contains an octamer motif (ATTTGCAT) which is a binding site for octamer transcription factor members of the POU domain family of DNA-binding proteins. Rex-1 reporter plasmids including this octamer site also exhibited reduced expression in F9 cells treated with RA. Thus, the octamer motif is a regulatory element required for the activity of the Rex-1 promoter in F9 stem cells, and this motif contributes to the negative regulation by RA of the transcription of the Rex-1 gene. As an initial confirmation of the in vivo relevance of the isolated fragment, a larger Rex-1 promoter fragment, also containing the octamer site, was able to promote expression of the bacterial lacZ gene in mouse embryos at the morula stage."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.13.5.2919-2928.1993"xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.13.5.2919-2928.1993"xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/author | "Kozak C.A."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/author | "Kozak C.A."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/author | "Rogers M.B."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/author | "Rogers M.B."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/author | "Gudas L.J."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/author | "Gudas L.J."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/author | "Hosler B.A."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/author | "Hosler B.A."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/pages | "2919-2928"xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/pages | "2919-2928"xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/title | "An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/title | "An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/8474450 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8474450 |
| http://purl.uniprot.org/citations/8474450 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8474450 |