| http://purl.uniprot.org/citations/8475064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8475064 | http://www.w3.org/2000/01/rdf-schema#comment | "The B-cell surface molecule CD22, when cross-linked, modulates signaling through the surface IgM (sIgM)-B-cell receptor (BCR) complex. Here we analyzed the basis of this interaction between CD22 and the human sIgM complex. After lysis of B cells or B-cell lines in digitonin, CD22 coimmunoprecipitated a kinase activity that in vitro-phosphorylated two polypeptides of 150 and 130 kDa on tyrosine residues. By immunoblot analysis with a rabbit anti-serum specific for a synthetic peptide of CD22, we found these proteins to be CD22 itself. Furthermore, the phosphorylated 150-kDa CD22 was found in the sIgM-BCR complex maintained by digitonin, along with Ig alpha/mb-1, Ig beta/B29, and a 75-kDa polypeptide precipitated by an antiserum specific to protein-tyrosine kinase PTK72. CD22 is likely to be an important signaling partner in the sIgM-BCR complex since it is very rapidly and strikingly phosphorylated after sIgM is cross-linked and since it contains the antigen recognition homology I (ARHI) motif, present in other antigen receptor molecules."xsd:string |
| http://purl.uniprot.org/citations/8475064 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.90.8.3236"xsd:string |
| http://purl.uniprot.org/citations/8475064 | http://purl.uniprot.org/core/author | "Leprince C."xsd:string |
| http://purl.uniprot.org/citations/8475064 | http://purl.uniprot.org/core/author | "Clark E.A."xsd:string |
| http://purl.uniprot.org/citations/8475064 | http://purl.uniprot.org/core/author | "Geahlen R.L."xsd:string |
| http://purl.uniprot.org/citations/8475064 | http://purl.uniprot.org/core/author | "Ledbetter J.A."xsd:string |
| http://purl.uniprot.org/citations/8475064 | http://purl.uniprot.org/core/author | "Draves K.E."xsd:string |
| http://purl.uniprot.org/citations/8475064 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8475064 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/8475064 | http://purl.uniprot.org/core/pages | "3236-3240"xsd:string |
| http://purl.uniprot.org/citations/8475064 | http://purl.uniprot.org/core/title | "CD22 associates with the human surface IgM-B-cell antigen receptor complex."xsd:string |
| http://purl.uniprot.org/citations/8475064 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/8475064 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8475064 |
| http://purl.uniprot.org/citations/8475064 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8475064 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH25-mappedCitation-8475064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8475064 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH73-mappedCitation-8475064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8475064 |
| http://purl.uniprot.org/uniprot/#_A0A075B6P5-mappedCitation-8475064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8475064 |
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| http://purl.uniprot.org/uniprot/#_P0CF74-mappedCitation-8475064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8475064 |
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| http://purl.uniprot.org/uniprot/#_A2KUC3-mappedCitation-8475064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8475064 |
| http://purl.uniprot.org/uniprot/#_A2NJV5-mappedCitation-8475064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8475064 |
| http://purl.uniprot.org/uniprot/#_A2NXD2-mappedCitation-8475064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8475064 |
| http://purl.uniprot.org/uniprot/#_A0M8Q6-mappedCitation-8475064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8475064 |