| http://purl.uniprot.org/citations/8483949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8483949 | http://www.w3.org/2000/01/rdf-schema#comment | "A 39-nt DNA sequence, the interferon gamma (IFN-gamma) response region (GRR), is necessary for the IFN-gamma-induced transcription of the high-affinity Fc receptor for IgG (Fc gamma RI) and sufficient for the IFN-gamma-induced transcription of transfected plasmids. By using extracts from IFN-gamma-treated cells, three protein complexes will assemble in vitro on a 9-nt core region in the 3' domain of the GRR. The sequence of this core resembles the IFN-gamma-activated sequence (GAS) described for the GBP gene. Mutations in this GAS core region prevent complex assembly and result in the loss of IFN-gamma induction of reporter constructs containing the mutation. In addition to the GAS core region, a 5' region of the GRR is necessary for optimal IFN-gamma induction and for formation of one of the DNA-protein complexes. By antibody reactivity, we show that a 91-kDa protein, first identified as a component of ISGF3, the IFN-alpha-induced transcription complex, is present in at least two of the DNA-protein complexes. IFN-alpha can induce the formation of the faster-migrating 91-kDa protein-GAS complex but not the slower-migrating complex. Furthermore, IFN-alpha does not result in appreciable transcriptional activation of Fc gamma RI or constructs containing the GRR. Thus, these data demonstrate that the IFN-gamma-activated 91-kDa protein is required for IFN-gamma induction of Fc gamma RI and suggest that an additional complex may be required for optimal expression and specificity."xsd:string |
| http://purl.uniprot.org/citations/8483949 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.90.9.4314"xsd:string |
| http://purl.uniprot.org/citations/8483949 | http://purl.uniprot.org/core/author | "Ravetch J.V."xsd:string |
| http://purl.uniprot.org/citations/8483949 | http://purl.uniprot.org/core/author | "Darnell J.E. Jr."xsd:string |
| http://purl.uniprot.org/citations/8483949 | http://purl.uniprot.org/core/author | "Feinman R."xsd:string |
| http://purl.uniprot.org/citations/8483949 | http://purl.uniprot.org/core/author | "Pearse R.N."xsd:string |
| http://purl.uniprot.org/citations/8483949 | http://purl.uniprot.org/core/author | "Shuai K."xsd:string |
| http://purl.uniprot.org/citations/8483949 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8483949 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/8483949 | http://purl.uniprot.org/core/pages | "4314-4318"xsd:string |
| http://purl.uniprot.org/citations/8483949 | http://purl.uniprot.org/core/title | "Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3."xsd:string |
| http://purl.uniprot.org/citations/8483949 | http://purl.uniprot.org/core/volume | "90"xsd:string |
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