| http://purl.uniprot.org/citations/8486289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8486289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8486289 | http://www.w3.org/2000/01/rdf-schema#comment | "The nucleotide (nt) sequence of a 3409-bp PvuII fragment carrying the self-defense gene (fmrO) of a fortimicin A (FmA; astromicin) producer, Micromonospora olivasterospora, was determined; four open reading frames (ORFs) exist in this region. Expression analysis of fmrO using the lac promoter in Escherichia coli revealed that ORF-3 encodes fmrO. ORF-1 was considered to encode a FmKH epimerase (fms11). ORF-2, ORF-3 and ORF-4 seemed to form an operon. No homology was detected between fmrO and the resistance-encoding gene fmrT of Streptomyces tenjimariensis, a producer of the Fm-group antibiotic, istamycin. Gene organization around the fmr genes differed considerably between M. olivasterospora and S. tenjimariensis. The deduced amino acid sequence of fmrO showed an identity of 30.8% to grmA of M. purpurea and 35.8% to grmB of M. rosea, respectively, suggesting that fmrO encodes a 16S rRNA methyltransferase. We found in M. purpurea a novel resistance gene distinct from grmA and highly similar to fmrO which conferred a resistance phenotype similar to that of fmrO. These results suggest that fmrO of M. olivasterospora and the two resistance-encoding genes of M. purpurea were derived from a common ancestral gene."xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(93)90617-c"xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(93)90617-c"xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/author | "Hasegawa M."xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/author | "Hasegawa M."xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/author | "Ohta T."xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/author | "Ohta T."xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/pages | "63-69"xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/pages | "63-69"xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/title | "Analysis of the self-defense gene (fmrO) of a fortimicin A (astromicin) producer, Micromonospora olivasterospora: comparison with other aminoglycoside-resistance-encoding genes."xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/title | "Analysis of the self-defense gene (fmrO) of a fortimicin A (astromicin) producer, Micromonospora olivasterospora: comparison with other aminoglycoside-resistance-encoding genes."xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/8486289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8486289 |
| http://purl.uniprot.org/citations/8486289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8486289 |
| http://purl.uniprot.org/citations/8486289 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8486289 |
| http://purl.uniprot.org/citations/8486289 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8486289 |
| http://purl.uniprot.org/uniprot/Q08325 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8486289 |
| http://purl.uniprot.org/uniprot/Q08328 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8486289 |