| http://purl.uniprot.org/citations/8486361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8486361 | http://www.w3.org/2000/01/rdf-schema#comment | "The biosynthesis of steroid hormones in the gonads and adrenal glands requires the activities of the enzyme 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta HSD) which catalyzes the NAD(+)-dependent dehydrogenation and subsequent delta 5-->delta 4 isomerization of delta 5-3 beta-hydroxysteroids to delta 4-3-ketosteroids. The mouse expresses four isoforms of 3 beta HSD. 3 beta HSD I is expressed in gonads and adrenal glands and appears to be the major steroidogenic form, 3 beta HSDs II and III are expressed in both liver and kidneys, and 3 beta HSD IV has been detected only in kidneys. To determine the genetic relationship between the 3 beta HSD isoforms, we have mapped the chromosomal locations of the four genes by linkage analysis using gene-specific probes derived from the 3' untranslated regions of 3 beta HSD cDNA clones. The four 3 beta HSD structural genes (Hsd3b) are closely linked within a segment of chromosome 3 that is conserved on human chromosome 1. The order of markers on Chr 3 surrounding Hsd3b is: centromere-Gba-(4.4 +/- 2.2)-Hsd3b-(3.3 +/- 1.9)-Tshb-(6.7 +/- 2.7)-Amy-1."xsd:string |
| http://purl.uniprot.org/citations/8486361 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.1993.1162"xsd:string |
| http://purl.uniprot.org/citations/8486361 | http://purl.uniprot.org/core/author | "Bain P.A."xsd:string |
| http://purl.uniprot.org/citations/8486361 | http://purl.uniprot.org/core/author | "Payne A.H."xsd:string |
| http://purl.uniprot.org/citations/8486361 | http://purl.uniprot.org/core/author | "Taylor B.A."xsd:string |
| http://purl.uniprot.org/citations/8486361 | http://purl.uniprot.org/core/author | "Meisler M.H."xsd:string |
| http://purl.uniprot.org/citations/8486361 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8486361 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/8486361 | http://purl.uniprot.org/core/pages | "219-223"xsd:string |
| http://purl.uniprot.org/citations/8486361 | http://purl.uniprot.org/core/title | "The genes encoding gonadal and nongonadal forms of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are closely linked on mouse chromosome 3."xsd:string |
| http://purl.uniprot.org/citations/8486361 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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