| http://purl.uniprot.org/citations/8491377 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8491377 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8491377 | http://www.w3.org/2000/01/rdf-schema#comment | "Early B-cell factor (EBF) was identified previously as a tissue-specific and differentiation stage-specific DNA-binding protein that participates in the regulation of the pre-B and B lymphocyte-specific mb-1 gene. Partial amino acid sequences obtained from purified EBF were used to isolate cDNA clones, which by multiple criteria encode EBF. The recombinant polypeptide formed sequence-specific complexes with the EBF-binding site in the mb-1 promoter. The cDNA hybridized to multiple transcripts in pre-B and B-cell lines, but transcripts were not detected at significant levels in plasmacytoma, T-cell, and nonlymphoid cell lines. Expression of recombinant EBF in transfected nonlymphoid cells strongly activated transcription from reporter plasmids containing functional EBF-binding sites. Analysis of DNA binding by deletion mutants of EBF identified an amino-terminal cysteine-rich DNA-binding domain lacking obvious sequence similarity to known transcription factors. DNA-binding assays with cotranslated wild-type and truncated forms of EBF indicated that the protein interacts with its site as a homodimer. Deletions delineated a carboxy-terminal dimerization region containing two repeats of 15 amino acids that show similarity with the dimerization domains of basic-helix-loop-helix proteins. Together, these data suggest that EBF represents a novel regulator of B lymphocyte-specific gene expression."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.7.5.760"xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.7.5.760"xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/author | "Belanger C."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/author | "Belanger C."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/author | "Grosschedl R."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/author | "Grosschedl R."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/author | "Hagman J."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/author | "Hagman J."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/author | "Travis A."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/author | "Travis A."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/author | "Turck W."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/author | "Turck W."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/pages | "760-773"xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/pages | "760-773"xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/title | "Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/title | "Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression."xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/8491377 | http://purl.uniprot.org/core/volume | "7"xsd:string |