| http://purl.uniprot.org/citations/8519686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8519686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8519686 | http://www.w3.org/2000/01/rdf-schema#comment | "Ornithine decarboxylase (ODC) expression is increased by growth factors and is obligatory for progression through the cell cycle in a wide variety of cell types. In this study, a variant human ODC cDNA was identified, sequenced, and used to probe mRNA levels in human breast tumor cell lines and xenografts. ODC mRNA was elevated about 3-fold in estrogen receptor-negative (ER-) tumors (MDA-MB-231) when compared with ER-positive (ER+) tumors (MCF-7), as assessed by quantitative autoradiographic analysis of in situ hybridization experiments. The pattern of ODC mRNA in MDA-MB-231 (ER-) xenografts was polarized to the extreme periphery of the tumor, whereas the distribution of ODC mRNA was more evenly distributed in MCF-7 (ER+) xenografts. This correlates with hematoxylin and eosin staining patterns, suggesting that ER+ and ER-xenografts have a differential dependence on host vasculature for growth factor supply. ODC mRNA was elevated 5-fold in MDA-MB-231 cells versus MCF-7 cells when analyzed in cell culture. These relative mRNA levels correlate with increased levels of "core" enhancer binding nuclear proteins in MDA-MB-231 cells over that detected in MCF-7 cells."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Miller J.A."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Miller J.A."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Wright P.S."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Wright P.S."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Chmielewski P.A."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Chmielewski P.A."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Cooper J.R."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Cooper J.R."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Cross-Doersen D.E."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Cross-Doersen D.E."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Flanagan M.A."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Flanagan M.A."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Streng K.A."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Streng K.A."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Wagner R.L."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/author | "Wagner R.L."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/name | "Cell Growth Differ."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/name | "Cell Growth Differ."xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/pages | "1097-1102"xsd:string |
| http://purl.uniprot.org/citations/8519686 | http://purl.uniprot.org/core/pages | "1097-1102"xsd:string |