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| http://purl.uniprot.org/citations/8520027 | http://www.w3.org/2000/01/rdf-schema#comment | "The T- and B-cell receptor (TCR and BCR) signal transduction processes involve a coordinated interplay between two classes of non-receptor protein tyrosine kinases (PTKs), the Src-family and the Syk/ZAP-70 family of PTKs. Following antigen-receptor stimulation, the Src-family of PTKs mediate the phosphorylation of tyrosine residues contained in a signalling motif localized in the TCR and BCR subunits. The phosphorylation of this signalling motif recruits the Syk/ZAP-70 family of PTKs into the antigen receptor complex. This mechanism requires the tandem SH2 domains in ZAP-70 complexing to two critically spaced phosphotyrosine residues within the signalling motif. The clustering of Syk/ZAP-70 and cross-talk between this family and the Src-PTKs regulates subsequent signalling events that lead to a variety of cellular responses, such as antibody secretion, lymphokine production, cytolytic activity, proliferation, differentiation and cell survival."xsd:string |
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| http://purl.uniprot.org/citations/8520027 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/8520027 | http://purl.uniprot.org/core/author | "van Oers N.S."xsd:string |
| http://purl.uniprot.org/citations/8520027 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8520027 | http://purl.uniprot.org/core/name | "Semin Immunol"xsd:string |
| http://purl.uniprot.org/citations/8520027 | http://purl.uniprot.org/core/pages | "227-236"xsd:string |
| http://purl.uniprot.org/citations/8520027 | http://purl.uniprot.org/core/title | "The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes."xsd:string |
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