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http://purl.uniprot.org/citations/8521472http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8521472http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8521472http://www.w3.org/2000/01/rdf-schema#comment"We have identified a novel 100 kDa coiled-coil protein, rabaptin-5, that specifically interacts with the GTP form of the small GTPase Rab5, a potent regulator of endocytic transport. It is mainly cytosolic, but a fraction colocalizes with Rab5 to early endosomes. Expression of a GTPase-deficient Rab5 mutant enhances the binding of rabaptin-5 to enlarged endosomes. Overexpression of rabaptin-5 alone is sufficient to promote expansion of early endosomes. Rab5 recruits rabaptin-5 to purified early endosomes in a GTP-dependent manner, demonstrating functional similarities with other members of the Ras superfamily. Immunodepletion of rabaptin-5 from cytosol strongly inhibits Rab5-dependent early endosome fusion. Rabaptin-5 is thus a Rab effector required for membrane docking and fusion."xsd:string
http://purl.uniprot.org/citations/8521472http://purl.org/dc/terms/identifier"doi:10.1016/0092-8674(95)90120-5"xsd:string
http://purl.uniprot.org/citations/8521472http://purl.org/dc/terms/identifier"doi:10.1016/0092-8674(95)90120-5"xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/author"Stenmark H."xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/author"Stenmark H."xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/author"Zerial M."xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/author"Zerial M."xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/author"Vitale G."xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/author"Vitale G."xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/author"Ulrich O."xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/author"Ulrich O."xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/pages"423-432"xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/pages"423-432"xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/title"Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion."xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/title"Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion."xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/volume"83"xsd:string
http://purl.uniprot.org/citations/8521472http://purl.uniprot.org/core/volume"83"xsd:string
http://purl.uniprot.org/citations/8521472http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8521472
http://purl.uniprot.org/citations/8521472http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8521472