| http://purl.uniprot.org/citations/8530383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8530383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8530383 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukins-2 and -15 (IL-2 and IL-15) are cytokines with overlapping but distinct biological effects. Their receptors share two subunits (the IL-2R beta and -gamma chains) that are essential for signal transduction. The IL-2 receptor requires an additional IL-2-specific alpha subunit for high affinity IL-2 binding. Recently, a murine IL-15-specific alpha subunit was identified, cloned, and shown to be structurally related to IL-2R alpha. However, the murine IL-15R alpha alone bound IL-15 with a 1000-fold higher affinity than that seen with IL-2R alpha and IL-2. We now extend these studies into the human system with the isolation of three differentially spliced human IL-15R alpha variants that are all capable of high affinity binding of IL-15. The cytoplasmic domain of IL-15R alpha, like that of IL-2R alpha, is dispensable for mitogenic signaling, suggesting that the primary role of the alpha chains is to confer high affinity binding. At high concentrations, IL-15, like IL-2, is able to signal through a complex of IL-2R beta and -gamma in the absence of the alpha subunit. Furthermore, the IL15RA and IL2RA genes have a similar intron-exon organization and are closely linked in both human and murine genomes. However, the distribution of expression of the IL-15R alpha is much wider than that of the IL-2R alpha, suggesting a broader range of cellular targets for IL-15."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.50.29862"xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.50.29862"xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Morris S.W."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Morris S.W."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Gilbert D.J."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Gilbert D.J."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Anderson D.M."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Anderson D.M."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Shapiro D.N."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Shapiro D.N."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Giri J."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Giri J."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Valentine V."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Valentine V."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Cosman D."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Cosman D."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Park L.S."xsd:string |
| http://purl.uniprot.org/citations/8530383 | http://purl.uniprot.org/core/author | "Park L.S."xsd:string |