| http://purl.uniprot.org/citations/8538742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8538742 | http://www.w3.org/2000/01/rdf-schema#comment | "The sequence of glucagon-like peptide-1 (7-36) amide (GLP-1) is completely conserved in all mammalian species studied, implying that it plays a critical physiological role. We have shown that GLP-1 and its specific receptors are present in the hypothalamus. No physiological role for central GLP-1 has been established. We report here that intracerebroventricular (ICV) GLP-1 powerfully inhibits feeding in fasted rats. ICV injection of the specific GLP-1-receptor antagonist, exendin (9-39), blocked the inhibitory effect of GLP-1 on food intake. Exendin (9-39) alone had no influence on fast-induced feeding but more than doubled food intake in satiated rats, and augmented the feeding response to the appetite stimulant, neuropeptide Y. Induction of c-fos is a marker of neuronal activation. Following ICV GLP-1 injection, c-fos appeared exclusively in the paraventricular nucleus of the hypothalamus and central nucleus of the amygdala, and this was inhibited by prior administration of exendin (9-39). Both of these regions of the brain are of primary importance in the regulation of feeding. These findings suggest that central GLP-1 is a new physiological mediator of satiety."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.org/dc/terms/identifier | "doi:10.1038/379069a0"xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Smith D.M."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Taylor G.M."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Bloom S.R."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Ghatei M.A."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Herbert J."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Choi S.J."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Edwards C.M."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Gunn I."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Beak S.A."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Heath M.M."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Lambert P.D."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Meeran K."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "O'Shea D."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Turton M.D."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/author | "Wilding J.P."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/pages | "69-72"xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/title | "A role for glucagon-like peptide-1 in the central regulation of feeding."xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://purl.uniprot.org/core/volume | "379"xsd:string |
| http://purl.uniprot.org/citations/8538742 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8538742 |
| http://purl.uniprot.org/citations/8538742 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8538742 |