| http://purl.uniprot.org/citations/8541831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8541831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8541831 | http://www.w3.org/2000/01/rdf-schema#comment | "We have cloned, sequenced, and expressed cDNAs encoding wild type human glutaryl-CoA dehydrogenase subunit, and have expressed a mutant enzyme found in a patient with glutaric acidemia type I. The mutant protein is expressed at the same level as the wild type in Escherichia coli, but has less than 1% of the activity of wild-type dehydrogenase. We also present evidence that the glutaryl-CoA dehydrogenase transcript is alternatively spliced in human fibroblasts and liver; the alternatively spliced mRNA, when expressed in E.coli, encodes a stable but inactive protein. Purified expressed human glutaryl-CoA dehydrogenase has kinetic constants similar to those of the previously purified porcine dehydrogenase. The primary translation product from in vitro transcribed glutaryl-CoA dehydrogenase mRNA is translocated into mitochondria and processed in the same manner as most other nuclear-encoded mitochondrial proteins. Human glutaryl-CoA dehydrogenase shows 53% sequence similarity to porcine medium chain acyl-CoA dehydrogenase, and these similarities were utilized to predict structure-function relationships in glutaryl-CoA dehydrogenase."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/4.9.1493"xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/4.9.1493"xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Biery B.J."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Biery B.J."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Frerman F.E."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Frerman F.E."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Isaya G."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Isaya G."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Goodman S.I."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Goodman S.I."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Digiulio K.A."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Digiulio K.A."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Goodman K.E."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Goodman K.E."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Kratz L.E."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/author | "Kratz L.E."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/pages | "1493-1498"xsd:string |
| http://purl.uniprot.org/citations/8541831 | http://purl.uniprot.org/core/pages | "1493-1498"xsd:string |