| http://purl.uniprot.org/citations/8552190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8552190 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite its widespread distribution on both lymphoid and myeloid cells, the biological role of the low-affinity immunoglobulin-G receptor, Fc gamma RII, is not fully understood. Defects in this receptor or its signalling pathway in B cells result in perturbations in immune-complex-mediated feedback inhibition of antibody production. We now report that Fc gamma RII-deficient animals display elevated immunoglobulin levels in response to both thymus-dependent and thymus-independent antigens. Additionally, the effector arm of the allergic response is perturbed in these mice. Mast cells from Fc gamma RII-/-are highly sensitive to IgG-triggered degranulation, in contrast to their wild-type counterparts. Fc gamma RII-deficient mice demonstrate an enhanced passive cutaneous analphylaxis reaction, the result of a decreased threshold for mast-cell activation by Fc gamma RIII cross-linking. These results demonstrate that Fc gamma RII acts as a general negative regulator of immune-complex-triggered activation in vivo for both the afferent and efferent limbs of the immune response. Exploiting this property offers new therapeutic opportunities for the treatment of allergic and autoimmune disorders."xsd:string |
| http://purl.uniprot.org/citations/8552190 | http://purl.org/dc/terms/identifier | "doi:10.1038/379346a0"xsd:string |
| http://purl.uniprot.org/citations/8552190 | http://purl.uniprot.org/core/author | "Ohmori H."xsd:string |
| http://purl.uniprot.org/citations/8552190 | http://purl.uniprot.org/core/author | "Ono M."xsd:string |
| http://purl.uniprot.org/citations/8552190 | http://purl.uniprot.org/core/author | "Ravetch J.V."xsd:string |
| http://purl.uniprot.org/citations/8552190 | http://purl.uniprot.org/core/author | "Hikida M."xsd:string |
| http://purl.uniprot.org/citations/8552190 | http://purl.uniprot.org/core/author | "Takai T."xsd:string |
| http://purl.uniprot.org/citations/8552190 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8552190 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8552190 | http://purl.uniprot.org/core/pages | "346-349"xsd:string |
| http://purl.uniprot.org/citations/8552190 | http://purl.uniprot.org/core/title | "Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/8552190 | http://purl.uniprot.org/core/volume | "379"xsd:string |
| http://purl.uniprot.org/citations/8552190 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8552190 |
| http://purl.uniprot.org/citations/8552190 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8552190 |
| http://purl.uniprot.org/uniprot/P08101#attribution-0395BD9997CE7DAD7671027A18578B46 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8552190 |
| http://purl.uniprot.org/uniprot/P08101#attribution-BBCB5D433C5998EAF62245931E6ABE62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8552190 |
| http://purl.uniprot.org/uniprot/P08508#attribution-BBCB5D433C5998EAF62245931E6ABE62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8552190 |
| http://purl.uniprot.org/uniprot/P01868#attribution-BBCB5D433C5998EAF62245931E6ABE62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8552190 |
| http://purl.uniprot.org/uniprot/P01872#attribution-BBCB5D433C5998EAF62245931E6ABE62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8552190 |
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| http://purl.uniprot.org/uniprot/P01869#attribution-BBCB5D433C5998EAF62245931E6ABE62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8552190 |
| http://purl.uniprot.org/uniprot/P05555#attribution-BBCB5D433C5998EAF62245931E6ABE62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8552190 |
| http://purl.uniprot.org/uniprot/P06800#attribution-BBCB5D433C5998EAF62245931E6ABE62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8552190 |
| http://purl.uniprot.org/uniprot/A0A075B6A3#attribution-BBCB5D433C5998EAF62245931E6ABE62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8552190 |