| http://purl.uniprot.org/citations/8553074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8553074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8553074 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by uncoupling the signal transduction process. Resensitization of GPCR responsiveness involves agonist-mediated receptor sequestration. Overexpression of beta-arrestins in human embryonic kidney cells rescued the sequestration of beta 2-adrenergic receptor (beta 2AR) mutants defective in their ability to sequester, an effect enhanced by simultaneous overexpression of beta-adrenergic receptor kinase 1. Wild-type beta 2AR sequestration was inhibited by the overexpression of two beta-arrestin mutants. These findings suggest that beta-arrestins play an integral role in GPCR internalization and thus serve a dual role in the regulation of GPCR function."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.271.5247.363"xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.271.5247.363"xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Caron M.G."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Caron M.G."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Barak L.S."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Barak L.S."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Menard L."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Menard L."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Ferguson S.S.G."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Ferguson S.S.G."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Colapietro A.-M."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Colapietro A.-M."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Downey W.E. III"xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/author | "Downey W.E. III"xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/pages | "363-366"xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/pages | "363-366"xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/title | "Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization."xsd:string |
| http://purl.uniprot.org/citations/8553074 | http://purl.uniprot.org/core/title | "Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization."xsd:string |