| http://purl.uniprot.org/citations/8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8562515 | http://www.w3.org/2000/01/rdf-schema#comment | "The response of T lymphocytes to superantigens requires expression of the appropriate TCR V beta gene products as well as the establishment of cellular interactions mediated by adhesion molecules. To study the role of intercellular adhesion molecule (ICAM)-1 in the response in vivo to superantigens, we have analyzed the effects induced by the bacterial superantigen Staphylococcus aureus enterotoxin B (SEB) in mice which have been made genetically deficient in ICAM-1. SEB treatment of wild-type mice causes proliferation, deletion and anergy of the SEB-reactive V beta 8+ T cell population. Here we show that cellular interactions mediated by ICAM-1 are not essential for the induction of anergy or for the deletion of CD4+ V beta 8+ or CD8+ V beta 8+ T cells, but are required for the proliferation of these peripheral T lymphocytes. This is the first demonstration in vivo that the absence of the co-stimulatory signals provided by the interaction of ICAM-1 with its specific ligands impairs the proliferation of SEB-reactive T cells. Interestingly, our study showed that SEB-induced proliferation of CD8+ V beta 8+ T cells from lymph nodes (not from spleen) is independent of the interactions mediated by ICAM-1."xsd:string |
| http://purl.uniprot.org/citations/8562515 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/7.10.1691"xsd:string |
| http://purl.uniprot.org/citations/8562515 | http://purl.uniprot.org/core/author | "Martinez C."xsd:string |
| http://purl.uniprot.org/citations/8562515 | http://purl.uniprot.org/core/author | "Springer T.A."xsd:string |
| http://purl.uniprot.org/citations/8562515 | http://purl.uniprot.org/core/author | "Gonzalo J.A."xsd:string |
| http://purl.uniprot.org/citations/8562515 | http://purl.uniprot.org/core/author | "Gutierrez-Ramos J.C."xsd:string |
| http://purl.uniprot.org/citations/8562515 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8562515 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/8562515 | http://purl.uniprot.org/core/pages | "1691-1698"xsd:string |
| http://purl.uniprot.org/citations/8562515 | http://purl.uniprot.org/core/title | "ICAM-1 is required for T cell proliferation but not for anergy or apoptosis induced by Staphylococcus aureus enterotoxin B in vivo."xsd:string |
| http://purl.uniprot.org/citations/8562515 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/8562515 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8562515 |
| http://purl.uniprot.org/citations/8562515 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8562515 |
| http://purl.uniprot.org/uniprot/#_P13597-mappedCitation-8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8562515 |
| http://purl.uniprot.org/uniprot/#_Q3THH5-mappedCitation-8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8562515 |
| http://purl.uniprot.org/uniprot/#_Q3U8M7-mappedCitation-8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8562515 |
| http://purl.uniprot.org/uniprot/#_Q922B3-mappedCitation-8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8562515 |
| http://purl.uniprot.org/uniprot/#_Q3UDJ5-mappedCitation-8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8562515 |
| http://purl.uniprot.org/uniprot/#_Q3UE52-mappedCitation-8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8562515 |
| http://purl.uniprot.org/uniprot/#_Q3TB10-mappedCitation-8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8562515 |
| http://purl.uniprot.org/uniprot/#_Q3TB21-mappedCitation-8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8562515 |
| http://purl.uniprot.org/uniprot/#_Q3U7Q9-mappedCitation-8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8562515 |
| http://purl.uniprot.org/uniprot/#_Q3U7T2-mappedCitation-8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8562515 |
| http://purl.uniprot.org/uniprot/#_Q3UAU5-mappedCitation-8562515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8562515 |