| http://purl.uniprot.org/citations/8566034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8566034 | http://www.w3.org/2000/01/rdf-schema#comment | "CD45 exon 6-deficient mice show a profound block of thymocyte development at a transitional differentiation step from immature CD4+ CD8+ to mature single-positive cells. Only a few T lymphocytes are observed in the periphery of such animals, but B cell development is not affected. We investigated whether mature B lymphocytes in CD45 exon 6-deficient mice have normal functions in the absence of CD45 expression and show here that CD45-defective B lymphocytes from CD45 exon 6-deficient mice have intact B lymphocyte functions, including T-dependent and T-independent antigen-specific antibody production and class switching in vivo if normal CD4+ T lymphocytes were adoptively transferred into the mutant mice. From these results, we conclude that CD45 expression on B lymphocytes is not essential for B cell responses following antigen stimulation in vivo. However, CD4+ T helper function was severely diminished in CD45 exon 6-deficient mice, suggesting that the requirements of CD45 molecules in antigen-specific response and development are different between T and B lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.1830251234"xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://purl.uniprot.org/core/author | "Kaneko M."xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://purl.uniprot.org/core/author | "Nomoto K."xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://purl.uniprot.org/core/author | "Kong Y.Y."xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://purl.uniprot.org/core/author | "Kishihara K."xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://purl.uniprot.org/core/author | "Sumichika H."xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8566034 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://purl.uniprot.org/core/pages | "3431-3436"xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://purl.uniprot.org/core/title | "Differential requirements of CD45 for lymphocyte development and function."xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/8566034 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8566034 |
| http://purl.uniprot.org/citations/8566034 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8566034 |
| http://purl.uniprot.org/uniprot/Q00609#attribution-45B0AE4B4B6CE57033203781D0EB0A30 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8566034 |
| http://purl.uniprot.org/uniprot/P20693#attribution-45B0AE4B4B6CE57033203781D0EB0A30 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8566034 |
| http://purl.uniprot.org/uniprot/P01868#attribution-45B0AE4B4B6CE57033203781D0EB0A30 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8566034 |
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| http://purl.uniprot.org/uniprot/P07750#attribution-45B0AE4B4B6CE57033203781D0EB0A30 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8566034 |
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