| http://purl.uniprot.org/citations/8566773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8566773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8566773 | http://www.w3.org/2000/01/rdf-schema#comment | "Two chitinase (CTS)-encoding genes (cts) from Coccidioides immitis (Ci), a respiratory fungal pathogen of humans, were cloned and sequenced. Both the genomic and cDNA sequences are presented. The transcription start points and poly(A)-addition sites were confirmed. The cts1 gene contains five introns and a 1281-bp ORF which translates a 427-amino-acid (aa) protein of 47.4 kDa. The cts2 gene contains two introns and a 2580-bp ORF which translates a 860-aa protein of 91.4 kDa. The deduced CTS1 protein showed highest homology to the Aphanocladium album and Trichoderma harzianum CTS (74% and 76%, respectively), while CTS2 showed highest homology to the CTS of Saccharomyces cerevisiae (Sc) and Candida albicans (47% and 51%, respectively). The putative N-terminal sequence of the mature CTS1 protein also showed 89% homology to the reported N-terminal sequence of a 48-kDa complement fixation antigen (CF-Ag) of Ci which has demonstrated chitinase activity. The CF-Ag is a clinically important antigen used in serodiagnosis of this fungal disease. CTS2 showed several of the conserved features of the Sc CTS, including putative catalytic and Ser/Thr-rich domains, and a C-terminal Cys-rich region. We propose that CTS1 and CTS2 of Ci are members of two distinct classes of fungal chitinases, an observation not previously reported for a single fungus."xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(95)00654-0"xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(95)00654-0"xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/author | "Cole G.T."xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/author | "Cole G.T."xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/author | "Kirkland T.N."xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/author | "Kirkland T.N."xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/author | "Pishko E.J."xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/author | "Pishko E.J."xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/pages | "173-177"xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/pages | "173-177"xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/title | "Isolation and characterization of two chitinase-encoding genes (cts1, cts2) from the fungus Coccidioides immitis."xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/title | "Isolation and characterization of two chitinase-encoding genes (cts1, cts2) from the fungus Coccidioides immitis."xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/8566773 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8566773 |
| http://purl.uniprot.org/citations/8566773 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8566773 |
| http://purl.uniprot.org/citations/8566773 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8566773 |
| http://purl.uniprot.org/citations/8566773 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8566773 |