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http://purl.uniprot.org/citations/8568858http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8568858http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8568858http://www.w3.org/2000/01/rdf-schema#comment"About 40% (350 kb) of the human MHC class II region has been sequenced and a coordinated effort to sequence the entire MHC is underway. In addition to the coding information (22 genes/pseudogenes), the non-coding sequences reveal novel information on the organisation and evolution of the MHC as demonstrated here by the example of a 200 kb contig that has been analysed for local and global features. In conjunction with cross-species comparisons, our results present new evidence on the structure of isochores, the evolutionary dynamics of repeat-mediated recombination and its effect on certain MHC encoded genes, and a higher than average degree of natural polymorphism that has implications for sequencing the human genome. We also report the finding of a class I-related pseudogene (HLA-ZI) in the middle of the class II region, which provides the first direct evidence for DNA exchange between these two related regions in man."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.org/dc/terms/identifier"doi:10.1006/jmbi.1996.0001"xsd:string
http://purl.uniprot.org/citations/8568858http://purl.org/dc/terms/identifier"doi:10.1006/jmbi.1996.0001"xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Beck S."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Beck S."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Jackson A."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Jackson A."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Kelly A."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Kelly A."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Abdulla S."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Abdulla S."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Sanseau P."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Sanseau P."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Glynne R.J."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Glynne R.J."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Trowsdale J."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Trowsdale J."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Thorpe K.L."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Thorpe K.L."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Alderton R.P."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Alderton R.P."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Gut I.G."xsd:string
http://purl.uniprot.org/citations/8568858http://purl.uniprot.org/core/author"Gut I.G."xsd:string