| http://purl.uniprot.org/citations/8569688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8569688 | http://www.w3.org/2000/01/rdf-schema#comment | "Caffeine is a base analogue and is known to affect a wide variety of cellular processes. In order to dissect genetically molecules which mediate the biological effects of caffeine, temperature-sensitive (ts) and caffeine-resistant mutants were isolated from fission yeast, Schizosaccharomyces pombe. Surprisingly, all twelve ts isolates contained a mutation in the same locus, crm1. Cells of the ts crm1 mutant showed an abnormal chromosome structure at the restrictive temperature, an elevated expression of Pap1-dependent transcription, and cross-resistance to an unrelated drug such as staurosporine. Overproduction of pap1+ also conferred caffeine resistance, whilst the resistance of the crm1 mutant is abolished in the pap1-background. These results show that the crm1+ gene is a major locus for caffeine resistance, which arises from Pap1-dependent transcriptional activation."xsd:string |
| http://purl.uniprot.org/citations/8569688 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf02191825"xsd:string |
| http://purl.uniprot.org/citations/8569688 | http://purl.uniprot.org/core/author | "Yanagida M."xsd:string |
| http://purl.uniprot.org/citations/8569688 | http://purl.uniprot.org/core/author | "Toda T."xsd:string |
| http://purl.uniprot.org/citations/8569688 | http://purl.uniprot.org/core/author | "Kumada K."xsd:string |
| http://purl.uniprot.org/citations/8569688 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8569688 | http://purl.uniprot.org/core/name | "Mol Gen Genet"xsd:string |
| http://purl.uniprot.org/citations/8569688 | http://purl.uniprot.org/core/pages | "59-68"xsd:string |
| http://purl.uniprot.org/citations/8569688 | http://purl.uniprot.org/core/title | "Caffeine-resistance in fission yeast is caused by mutations in a single essential gene, crm1+."xsd:string |
| http://purl.uniprot.org/citations/8569688 | http://purl.uniprot.org/core/volume | "250"xsd:string |
| http://purl.uniprot.org/citations/8569688 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8569688 |
| http://purl.uniprot.org/citations/8569688 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8569688 |
| http://purl.uniprot.org/uniprot/#_P14068-mappedCitation-8569688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8569688 |
| http://purl.uniprot.org/uniprot/#_P41878-mappedCitation-8569688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8569688 |
| http://purl.uniprot.org/uniprot/#_Q01663-mappedCitation-8569688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8569688 |
| http://purl.uniprot.org/uniprot/P14068 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8569688 |
| http://purl.uniprot.org/uniprot/P41878 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8569688 |
| http://purl.uniprot.org/uniprot/Q01663 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8569688 |