| http://purl.uniprot.org/citations/8590311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8590311 | http://www.w3.org/2000/01/rdf-schema#comment | "We have constructed expression clones for mature rat interleukin-1 beta (IL-1 beta). Using these clones, rat recombinant IL-1 beta (rrIL-1 beta) was prepared and purified by a single-step cation-exchange chromatography method. In addition, synthetic rrIL-1 beta mRNA was transcribed and used to synthesize radiolabeled 35S-rrIL-1 beta for binding studies. The rrIL-1 beta produced was demonstrated to have IL-1 bioactivity in a mouse thymocyte proliferation assay, in which it could be blocked by inclusion of human recombinant IL-1 receptor antagonist (hrIL-1Ra). Similarly, rrIL-1 beta induced LIF mRNA expression in cultured rat sympathetic ganglia. In each case, the maximal dose of rrIL-1 beta was similar to that of human IL-1 beta. However, the peak response in rat tissue was twofold higher with rat IL-1 beta than with human IL-1 beta. The expression of rrIL-1 beta provides a useful tool for studying IL-1 receptors in rat, in which human and mouse IL-1 beta have been found to bind poorly. Species-specific activity of rat IL-1 beta may correlate with compensatory ionic properties of rat IL-1 receptor."xsd:string |
| http://purl.uniprot.org/citations/8590311 | http://purl.org/dc/terms/identifier | "doi:10.1089/jir.1995.15.985"xsd:string |
| http://purl.uniprot.org/citations/8590311 | http://purl.uniprot.org/core/author | "Bai Y."xsd:string |
| http://purl.uniprot.org/citations/8590311 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/8590311 | http://purl.uniprot.org/core/author | "Hart R.P."xsd:string |
| http://purl.uniprot.org/citations/8590311 | http://purl.uniprot.org/core/author | "Ganea D."xsd:string |
| http://purl.uniprot.org/citations/8590311 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8590311 | http://purl.uniprot.org/core/name | "J Interferon Cytokine Res"xsd:string |
| http://purl.uniprot.org/citations/8590311 | http://purl.uniprot.org/core/pages | "985-992"xsd:string |
| http://purl.uniprot.org/citations/8590311 | http://purl.uniprot.org/core/title | "Species-specific activity of rat recombinant interleukin-1 beta."xsd:string |
| http://purl.uniprot.org/citations/8590311 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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