| http://purl.uniprot.org/citations/8598041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8598041 | http://www.w3.org/2000/01/rdf-schema#comment | "H2-M is a nonconventional major histocompatibility complex (MHC) class II molecule that has been implicated in the loading of peptides onto conventional class II molecules. We generated mice with a targeted mutation in the H2-Ma gene, which encodes a subunit for H2-M. Although the mutant mice express normal class II cell surface levels, these are structurally distinct from the compact SDS-resistant complexes expressed by wild-type cells and are predominantly bound by class II-associated invariant chain peptides (CLIPs). Cells from these animals are unable to present intact protein antigens to class II-restricted T cells and show reduced capacity to present exogenous peptides. Numbers of mature CD4+ T lymphocytes in mutant mice are reduced 3-to 4-fold and exhibit altered reactivities. Overall, this phenotype establishes an important role for H2-M in regulating MHC class II function in vivo and supports the notion that self-peptides contribute to the specificity of T cell positive selection."xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81030-2"xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://purl.uniprot.org/core/author | "Ruley H.E."xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://purl.uniprot.org/core/author | "Martin W.D."xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://purl.uniprot.org/core/author | "Hicks G.G."xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://purl.uniprot.org/core/author | "Van Kaer L."xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://purl.uniprot.org/core/author | "Mendiratta S.K."xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://purl.uniprot.org/core/author | "Leva H.I."xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8598041 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://purl.uniprot.org/core/pages | "543-550"xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://purl.uniprot.org/core/title | "H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection."xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://purl.uniprot.org/core/volume | "84"xsd:string |
| http://purl.uniprot.org/citations/8598041 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8598041 |
| http://purl.uniprot.org/citations/8598041 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8598041 |
| http://purl.uniprot.org/uniprot/P28078#attribution-0BA9370269975B29093039262A122460 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8598041 |
| http://purl.uniprot.org/uniprot/P06343#attribution-4799EA96592D78EBDCD47C6483C40158 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8598041 |
| http://purl.uniprot.org/uniprot/P14483#attribution-4799EA96592D78EBDCD47C6483C40158 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8598041 |
| http://purl.uniprot.org/uniprot/P01921#attribution-4799EA96592D78EBDCD47C6483C40158 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8598041 |
| http://purl.uniprot.org/uniprot/P06342#attribution-4799EA96592D78EBDCD47C6483C40158 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8598041 |
| http://purl.uniprot.org/uniprot/P06345#attribution-4799EA96592D78EBDCD47C6483C40158 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8598041 |
| http://purl.uniprot.org/uniprot/P06346#attribution-4799EA96592D78EBDCD47C6483C40158 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8598041 |
| http://purl.uniprot.org/uniprot/P04227#attribution-4799EA96592D78EBDCD47C6483C40158 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8598041 |
| http://purl.uniprot.org/uniprot/P14437#attribution-4799EA96592D78EBDCD47C6483C40158 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8598041 |