| http://purl.uniprot.org/citations/8598196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8598196 | http://www.w3.org/2000/01/rdf-schema#comment | "Stimulation of the prolactin receptor (PRLR), a member of the cytokine/growth hormone receptor family, results in activation of the associated Jak2 tyrosine kinase and downstream signaling pathways. We report that PTP1D, a cytoplasmic protein tyrosine phosphatase containing two Src homology 2 (SH2) domains, physically associates with the PRLR-Jak2 complex and is tyrosine-phosphorylated upon stimulation with prolactin. The formation of the trimeric PRLR-Jak2-PTP1D complex is critical for transmission of a lactogenic signal, while PTP1D phosphorylation is necessary, but not sufficient. The dominant negative inhibitory effect of a phosphatase-deficient mutant on expression of a beta-casein promoter-controlled reporter gene is evidence for an essential role of fully functional PTP1D in the regulation of milk protein gene transcription."xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1996.tb00341.x"xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/author | "Ullrich A."xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/author | "Ali S."xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/author | "Lebrun J.J."xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/author | "Kelly P.A."xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/author | "Vogel W."xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/author | "Kharitonenkov A."xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/pages | "135-142"xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/title | "PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation."xsd:string |
| http://purl.uniprot.org/citations/8598196 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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