| http://purl.uniprot.org/citations/8601481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8601481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8601481 | http://www.w3.org/2000/01/rdf-schema#comment | "mes-3 is one of four maternal-effect sterile genes that encode maternal components required for normal postembryonic development of the germ line in Caenorhabditis elegans. mes-3 mutant mothers produce sterile progeny, which contain few germ cells and no gametes. This terminal phenotype reflects two problems: reduced proliferation of the germ line and germ cell death. Both the appearance of the dying germ cells and the results of genetic tests indicate that germ cells in mes-3 animals undergo a necrotic-like death, not programmed cell death. The few germ cells that appear healthy in mes-3 worms do not differentiate into gametes, even after elimination of the signaling pathway that normally maintains the undifferentiated population of germ cells. Thus, mes-3 encodes a maternally supplied product that is required both for proliferation of the germ line and for maintenance of viable germ cells that are competent to differentiate into gametes. Cloning and molecular characterization of mes-3 revealed that it is the upstream gene in an operon. The genes in the operon display parallel expression patterns; transcripts are present throughout development and are not restricted to germ-line tissue. Both mes-3 and the downstream gene in the operon encode novel proteins."xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/141.4.1383"xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/141.4.1383"xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/author | "Strome S."xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/author | "Strome S."xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/author | "Capowski E.E."xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/author | "Capowski E.E."xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/author | "Paulsen J.E."xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/author | "Paulsen J.E."xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/pages | "1383-1398"xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/pages | "1383-1398"xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/title | "Phenotypic and molecular analysis of mes-3, a maternal-effect gene required for proliferation and viability of the germ line in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/title | "Phenotypic and molecular analysis of mes-3, a maternal-effect gene required for proliferation and viability of the germ line in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/8601481 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8601481 |
| http://purl.uniprot.org/citations/8601481 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8601481 |
| http://purl.uniprot.org/citations/8601481 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8601481 |
| http://purl.uniprot.org/citations/8601481 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8601481 |