| http://purl.uniprot.org/citations/8602223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8602223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8602223 | http://www.w3.org/2000/01/rdf-schema#comment | "A general property of signal transduction pathways is that prolonged stimulation decreases responsiveness, a phenomenon termed desensitization. Yeast cells stimulated with mating pheromone activate a heterotrimeric G-protein-linked, MAP-kinase-dependent signalling pathway that induces G1-phase cell-cycle arrest and morphological differentiation (reviewed in refs 1, 2). Eventually the cells desensitize to pheromone and resume growth. Genetic studies have demonstrated the relative importance of a desensitization mechanism that uses the SST2 gene product, Sst2p. Here we identify a mammalian gene family termed RGS (for regulator of G-protein signalling) that encodes structural and functional homologues of Sst2p. Introduction of RGS family members into yeast blunts signal transduction through the pheromone-response pathway. Like SST2 (refs 8-10), they negatively regulate this pathway at a point upstream or at the level of the G protein. The RGS family members also markedly impair MAP kinase activation by mammalian G-protein-linked receptors, indicating the existence and importance of an SST2-like desensitization mechanism in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.org/dc/terms/identifier | "doi:10.1038/379742a0"xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.org/dc/terms/identifier | "doi:10.1038/379742a0"xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/author | "Kehrl J.H."xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/author | "Kehrl J.H."xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/author | "Blumer K.J."xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/author | "Blumer K.J."xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/author | "Druey K.M."xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/author | "Druey K.M."xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/author | "Kang V.H."xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/author | "Kang V.H."xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/pages | "742-746"xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/pages | "742-746"xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/title | "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family."xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/title | "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family."xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/volume | "379"xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://purl.uniprot.org/core/volume | "379"xsd:string |
| http://purl.uniprot.org/citations/8602223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8602223 |
| http://purl.uniprot.org/citations/8602223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8602223 |