| http://purl.uniprot.org/citations/8605036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8605036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8605036 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular smooth muscle cells (VSMCs) are known to produce activins, bone morphogenetic proteins and transforming growth factor-betas (TGF-betas). To determine whether these TGF-beta superfamily members exert autocrine effects on VSMCs we examined whether specific type I receptors (ALKs) for such peptides were expressed by the cells. RNA from both quiescent or growth-factor-activated VSMCs was reverse transcribed then cDNAs encoding ALK-2, ALK-3, ALK-5, and ALK-6 were amplified and characterised using specific PCR primers. All four ALK mRNAs were abundantly expressed. The ALK-5 fragment harbored a deletion of 12 nucleotides, removing 4 extracellular amino acids (Gly-Pro-Ser-Val) adjacent to its transmembrane domain. This deletion, which may arise from anomalous splicing of heteronuclear RNA, is likely to influence formation of the ALK-5:type II receptor complex through conformational changes associated with removal of a putative hinge region containing proline. Our finding that multiple ALKs are expressed by VSMCs would account for the multiplicity of effects TGF-beta peptides exert on these cells."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1996.0282"xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1996.0282"xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/author | "Agrotis A."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/author | "Agrotis A."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/author | "Samuel M."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/author | "Samuel M."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/author | "Bobik A."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/author | "Bobik A."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/author | "Prapas G."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/author | "Prapas G."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/pages | "613-618"xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/pages | "613-618"xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/title | "Vascular smooth muscle cells express multiple type I receptors for TGF-beta, activin, and bone morphogenetic proteins."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/title | "Vascular smooth muscle cells express multiple type I receptors for TGF-beta, activin, and bone morphogenetic proteins."xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/volume | "219"xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://purl.uniprot.org/core/volume | "219"xsd:string |
| http://purl.uniprot.org/citations/8605036 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8605036 |
| http://purl.uniprot.org/citations/8605036 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8605036 |