| http://purl.uniprot.org/citations/8608414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8608414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8608414 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumors such as sclerosing hemangiomas are sometimes associated with hypophosphatemia and osteomalacia, both of which disappear on removal of the tumor. We identified a heat labile, 8,000-25,000 dalton, inhibitor of renal epithelial phosphate transport in supernatants of cultured sclerosing hemangioma cells obtained from a patient with oncogenic osteomalacia and hypophosphatemia. The inhibitor does not alter glucose or alanine transport in renal epithelial cells, and has a mechanism of cellular action distinct from that of parathyroid hormone (PTH) in that it inhibits phosphate transport in renal epithelia without increasing concentrations of cyclic 3',5' adenosine monophosphate (cAMP); it's activity is not blocked by a PTH receptor antagonist. Sclerosing hemangioma cells also produce a material that cross-reacts with antisera directed against PTH and tumor tissue sections immunostain with PTH antibodies. We have characterized a cDNA that encodes the PTH immunoreactive material. In its longest open reading frame the cDNA encodes a protein of 381 amino acids that does not resemble PTH in its primary structure. Opossum kidney cells transfected with the cDNA do not produce a product that inhibits phosphate transport. Dialysates from patients with end-stage renal disease also contain a substance(s) that inhibits phosphate and glucose transport in opossum kidney cells. The inhibitor(s) of phosphate uptake in dialysates is a heat labile, approximately 30,000 dalton substance that inhibits phosphate transport by a cAMP-independent mechanism. Determination of the structures and physiology of these phosphate transport inhibitors is likely to yield insights into the control of phosphate homeostasis."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/author | "Cai Q."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/author | "Cai Q."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/author | "Kumar R."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/author | "Kumar R."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/author | "Haugen J.D."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/author | "Haugen J.D."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/author | "Londowski J.M."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/author | "Londowski J.M."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/author | "Wieben E.D."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/author | "Wieben E.D."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/name | "Proc. Assoc. Am. Physicians"xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/name | "Proc. Assoc. Am. Physicians"xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/pages | "296-305"xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/pages | "296-305"xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/title | "Inhibitors of renal epithelial phosphate transport in tumor-induced osteomalacia and uremia."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/title | "Inhibitors of renal epithelial phosphate transport in tumor-induced osteomalacia and uremia."xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/8608414 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8608414 |
| http://purl.uniprot.org/citations/8608414 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8608414 |