| http://purl.uniprot.org/citations/8609387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8609387 | http://www.w3.org/2000/01/rdf-schema#comment | "The development of CD8+ intestinal intraepithelial T lymphocytes (IEL) was analyzed in mice that are deficient in the expression of MHC class I molecules, owing to either a mutated beta 2-microglobulin (beta 2m) gene or a mutated transporter associated with Ag processing 1 (TAP1) gene, and in mice doubly homozygous for beta 2m and TAPI mutations. In all mutant mice, the population size of major CD8 alpha alpha+ and CD8 alpha beta+ alpha beta-IEL subsets was reduced drastically, and this resulted in a conspicuous decrease in the total number of alpha beta-IEL. Concomitantly, a compensatory two-to threefold increase in the number of gamma delta-IEL consisting mostly of CD8 alpha alpha+ subset was noted. In radiation bone marrow chimeras, this wild-type/mutant phenotype was determined by the genotype of radioresistant host cells, but was not determined by the genotype of reconstituting bone marrow-derived cells. In beta 2m X TCR-delta double mutant mice, however, the CD8 alpha alpha+ but not CD8 alpha beta+ alpha beta-IEL subset expanded dramatically. Thus, in the absence of gamma delta-IEL, alpha beta-IEL in beta 2m-deficient mice outnumbered those in wild-type littermates. These results indicate that the generation of CD8 alpha alpha+ lymphocyte population of alpha beta- and gamma delta-IEL is not dependent, but that of CD8 alpha beta+ lymphocyte population of alpha beta-IEL is dependent on beta 2m-and/or TAP1-dependent MHC class I molecules, expressed by the controlling cells present in the anatomical site, where the development of IEL takes place."xsd:string |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/author | "Ishikawa H."xsd:string |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/author | "Kondo Y."xsd:string |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/author | "Kawaguchi M."xsd:string |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/author | "Obana S."xsd:string |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/author | "Fujiura Y."xsd:string |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/author | "Nanno M."xsd:string |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/pages | "2710-2715"xsd:string |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/title | "Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/8609387 | http://purl.uniprot.org/core/volume | "156"xsd:string |
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