| http://purl.uniprot.org/citations/8615788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8615788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8615788 | http://www.w3.org/2000/01/rdf-schema#comment | "(15S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid (15-HETE) suppresses in ionophore-A23187-stimulated human polymorphonuclear leucocytes (PMN) the conversion of exogenous arachidonic acid into leukotriene B(4) (LTB4) and (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid (5-HETE). However, contrary to earlier suggestions, 15-HETE is not a genuine 5-lipoxygenase inhibitor under these conditions, but rather suppresses the 5-lipoxygenation of arachidonic acid by switching-over of substrate utilization, as judged from a sizeable formation of labelled (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetr aen oic acid (5,15-diHETE) from 15-[1(-14)C]HETE. Identical results were obtained with human recombinant 5-lipoxygenase. In PMN the formation of 5,15-diHETE is strongly stimulated by either hydroperoxypolyenoic fatty acids or arachidonic acid, suggesting a crucial role of the hydroperoxide tone of the cell. A comparison of a selection of hydroxypolyenoic fatty acids with respect to their capability of suppressing 5-lipoxygenation of arachidonic acid revealed that 15-mono-hydroxyeicosanoids throughout exhibit the highest inhibitory potencies, whereas the other HETEs, 5,15-diHETE as well as octadecanoids, are modest or poor inhibitors. The R and S enantiomers of 15-HETE do not differ from each other, excluding a receptor-like binding of the 15-hydroxy group."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3140911"xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3140911"xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/author | "Kuehn H."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/author | "Kuehn H."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/author | "Ludwig P."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/author | "Ludwig P."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/author | "Schewe T."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/author | "Schewe T."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/author | "Petrich K."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/author | "Petrich K."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/pages | "911-916"xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/pages | "911-916"xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/title | "The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/title | "The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action."xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/8615788 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8615788 |
| http://purl.uniprot.org/citations/8615788 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8615788 |