| http://purl.uniprot.org/citations/8617202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8617202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8617202 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian Clk/Sty is the prototype for a family of dual specificity kinases (termed LAMMER kinases) that have been conserved in evolution, but whose physiological substrates are unknown. In a yeast two-hybrid screen, the Clk/Sty kinase specifically interacted with RNA binding proteins, particularly members of the serine/arginine-rich (SR) family of splicing factors. Clk/Sty itself has an serine/arginine-rich non-catalytic N-terminal region which is important for its association with SR splicing factors. In vitro, Clk/Sty efficiently phosphorylated the SR family member ASF/SF2 on serine residues located within its serine/arginine-rich region (the RS domain). Tryptic phosphopeptide mapping demonstrated that the sites on ASF/SF2 phosphorylated in vitro overlap with those phosphorylated in vivo. Immunofluorescence studies showed that a catalytically inactive form of Clk/Sty co-localized with SR proteins in nuclear speckles. Overexpression of the active Clk/Sty kinase caused a redistribution of SR proteins within the nucleus. These results suggest that Clk/Sty kinase directly regulates the activity and compartmentalization of SR splicing factors."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1996.tb00357.x"xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1996.tb00357.x"xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Pawson T."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Pawson T."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Prasad J."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Prasad J."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Andrews B."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Andrews B."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Colwill K."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Colwill K."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Manley J.L."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Manley J.L."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Bell J.C."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Bell J.C."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Duncan P.I."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/author | "Duncan P.I."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/pages | "265-275"xsd:string |
| http://purl.uniprot.org/citations/8617202 | http://purl.uniprot.org/core/pages | "265-275"xsd:string |