| http://purl.uniprot.org/citations/8617941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8617941 | http://www.w3.org/2000/01/rdf-schema#comment | "MHC class I molecules bind peptides that are translocated from the cytosol into the endoplasmic reticulum by the peptide transporter associated with antigen processing (TAP). Class I heterodimers have been shown to associate with TAP and are released when loaded with peptide. Here, we show the existence of two pools of class I heterodimers, one associated with TAP and one that is free. Whereas the free pool is recognized by the class I-specific Ab W6/32, the TAP-associated pool is not. Analysis of several class I alleles shows binding to TAP with different efficiencies, even at the earliest time points of MHC class I assembly. Most HLA-A and -C alleles tested interacted efficiently with TAP, whereas a considerable number of HLA-B alleles associated very inefficiently or not at all with TAP. This was also observed in cells with nonfunctional TAP. Sequence comparison of the different class I alleles allowed the definition of amino acids in the peptide binding groove that might be involved in TAP association. Binding of peptides to two different pools of class I heterodimers may ensure efficient peptide association in an environment where peptides have a short life span."xsd:string |
| http://purl.uniprot.org/citations/8617941 | http://purl.uniprot.org/core/author | "Neefjes J."xsd:string |
| http://purl.uniprot.org/citations/8617941 | http://purl.uniprot.org/core/author | "Zang X."xsd:string |
| http://purl.uniprot.org/citations/8617941 | http://purl.uniprot.org/core/author | "Neisig A."xsd:string |
| http://purl.uniprot.org/citations/8617941 | http://purl.uniprot.org/core/author | "Wubbolts R."xsd:string |
| http://purl.uniprot.org/citations/8617941 | http://purl.uniprot.org/core/author | "Melief C."xsd:string |
| http://purl.uniprot.org/citations/8617941 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8617941 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/8617941 | http://purl.uniprot.org/core/pages | "3196-3206"xsd:string |
| http://purl.uniprot.org/citations/8617941 | http://purl.uniprot.org/core/title | "Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing."xsd:string |
| http://purl.uniprot.org/citations/8617941 | http://purl.uniprot.org/core/volume | "156"xsd:string |
| http://purl.uniprot.org/citations/8617941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8617941 |
| http://purl.uniprot.org/citations/8617941 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8617941 |
| http://purl.uniprot.org/uniprot/P04439#attribution-1D357D555387E536D8AB3BFBB6C25243 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8617941 |
| http://purl.uniprot.org/uniprot/P10321#attribution-1D357D555387E536D8AB3BFBB6C25243 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8617941 |
| http://purl.uniprot.org/uniprot/P01889#attribution-1D357D555387E536D8AB3BFBB6C25243 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8617941 |