| http://purl.uniprot.org/citations/8619862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8619862 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular slime mold Dictyostelium discoideum produces tetrahydrodictyopterin, the D-threo-isomer of tetrahydrobiopterin. During cyclic AMP coordinated aggregation, the G protein linked signalling pathway is involved in the regulation of the initial enzyme GTP cyclohydrolase I [M. Gütlich et al., Biochem. J. 314, 95-101 (1996)]. We now find that cyclic AMP stimulated binding of GTPgammaS to the membrane fraction is inhibited by tetrahydrodictyopterin and tetrahydrobiopterin. Inhibition was a function of GTPgammaS concentration and the analysis of the kinetic data pointed to a competitive type of inhibition. The inhibition of G protein activation was accompanied by a loss of adenylyl cyclase activation. Because the GTPgammaS- and G protein-dependent reduction of receptor affinity for cyclic AMP was also attenuated, we conclude that tetrahydrodictyopterin and tetrahydrobiopterin interfere with activation of G proteins by inhibiting GDP-GTP exchange."xsd:string |
| http://purl.uniprot.org/citations/8619862 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1996.0602"xsd:string |
| http://purl.uniprot.org/citations/8619862 | http://purl.uniprot.org/core/author | "Ziegler I."xsd:string |
| http://purl.uniprot.org/citations/8619862 | http://purl.uniprot.org/core/author | "Gutlich M."xsd:string |
| http://purl.uniprot.org/citations/8619862 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8619862 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/8619862 | http://purl.uniprot.org/core/pages | "368-373"xsd:string |
| http://purl.uniprot.org/citations/8619862 | http://purl.uniprot.org/core/title | "Tetrahydropterins interfere with the G protein pathway in Dictyostelium discoideum."xsd:string |
| http://purl.uniprot.org/citations/8619862 | http://purl.uniprot.org/core/volume | "221"xsd:string |
| http://purl.uniprot.org/citations/8619862 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8619862 |
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| http://purl.uniprot.org/uniprot/Q03100#attribution-9C1173BAA91017F67E3BE621DBDC5333 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8619862 |
| http://purl.uniprot.org/uniprot/#_Q03100-mappedCitation-8619862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8619862 |
| http://purl.uniprot.org/uniprot/#_Q94465-mappedCitation-8619862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8619862 |
| http://purl.uniprot.org/uniprot/Q03100 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8619862 |
| http://purl.uniprot.org/uniprot/Q94465 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8619862 |