| http://purl.uniprot.org/citations/8620531 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8620531 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8620531 | http://www.w3.org/2000/01/rdf-schema#comment | "Telomeres, the nucleoprotein complexes at the ends of eukaryotic chromosomes, are essential for chromosome stability. In the yeast S. cerevisiae, telomeric DNA is bound in a sequence-specific manner by RAP1, a multifunctional protein also involved in transcriptional regulation. Here we report the crystal structure of the DNA-binding domain of RAP1 in complex with telomeric DNA site at 2.25 A resolution. The protein contains two similar domains that bind DNA in a tandem orientation, recognizing a tandemly repeated DNA sequence. The domains are structurally related to the homeodomain and the proto-oncogene Myb, but show novel features in their DNA-binding mode. A structured linker between the domains and a long C-terminal tail contribute to the binding specificity. This structure provides insight into the recognition of the conserved telomeric DNA sequences by a protein."xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81088-0"xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81088-0"xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/author | "Rhodes D."xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/author | "Rhodes D."xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/author | "Chapman L."xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/author | "Chapman L."xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/author | "Giraldo R."xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/author | "Giraldo R."xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/author | "Koenig P."xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/author | "Koenig P."xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/pages | "125-136"xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/pages | "125-136"xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/title | "The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA."xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/title | "The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA."xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/8620531 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8620531 |
| http://purl.uniprot.org/citations/8620531 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8620531 |